Shared Flashcard Set

Details

Systemic HTN
Pharm 2 test 2
25
Health Care
Graduate
03/03/2009

Additional Health Care Flashcards

 


 

Cards

Term
Primary HTN
Definition

MOST COMMON

 

No identifiable cause

Term
Secondary HTN
Definition

Results from underlying cause:

Renal Dz

Coarct of Aorta

Hormonal

Pregnancy

Term

3 Objectives for pt w/ HTN

Definition

1. Assess lifestyle and other CV risks

2. reveal identifiable causes

3. asses presence/absence of TOD and CVD

Term
goal of therapy for HTN
Definition

reduction of CV and renal morbidity

 

Term
1st line of tx against HTN
Definition

Lifestyle Mods

 

-reduces BP

-enhances drug effects

-decr. CV risk

Term
First line of DRUG therapy for most pts w/ HTN
Definition

Thiazides

 

****Enhance efficacy of multidrug regimen****

 

Safe w/ ACEI/ARB, BB, and CCB's

Term
2nd line of drug therapy for HTN
Definition

**when single drug fails BP > 20/10 from goal

 

-different class (ACEI/ARB, BB, CCB)

Term
Once tx is initiate how often do you f/u
Definition

monthly until BP goal is reached-> q 3-6 mos

 

**more frequent if stage 2 or comorbids

 

-monitor K and creatinine 2x/yr

Term
Pts w/ DM and HTN are @ > risk of
Definition

CV events

 

**require more aggressive tx to prevent

nephropathy, MI, stroke

Term
HTN emergency
Definition

BP > 220/130, with disc edema, TOD:

severe perioperative HTN

 

Goal: pt reduction BP with sx relief

Term
HTN emergencies include
Definition

HTN encephalopathy

HTN nephropathy

brain bleed

aortic dissection

preeclamp/eclamp

pulm. edema

unstable angina/MI

Term
Malignant HTN
Definition

encephalopathy/nephropathy w/ papilledema

 

ALWAYS REQUIRES IV DRUGS!!

Term

initial goal of malignant HTN

Definition

reduce BP by 25% w/i 1 hr and try for

160/110 w/i 2-6 hrs

Term
4 major categories of drugs for HTN
Definition

1. Diuretic

2 Sympatholytics

3. Angiotensin inhibitors

4. Vasodilators

Term
Sympatholytics
Definition

1. Adrenergic receptor blockers:

-BB, Alpha blockers

2. Centrally acting alpha 2 agonists

Term
non-selective BB for HTN
Definition

propranolol

timolol

nadolol

pindolol

Term
non-selective BB act where/how
Definition

B1 and B2 receptors

 

produce negative chronotropic, inotropic, and dromotropic effects

Term
pindolol is different from other non-selective BB bc
Definition

it has ISA (intrinsic sympathomimetic agonist)

which can lower membrane-stabilizing activity

 

***only used to tx HTN***

Term
Selective BB work by
Definition

> affinity for B1 (less bronchospasm)

 

*w/ incr dosage, can still block some B2's

Term
Acebutolol uses
Definition

d/t low ISA

HTN, cardiac dysrhythmias

 

Long DOA (oral)

Term
Metoprolol metabolized by
Definition
P450 (IV and oral)
Term
Esmolol uses
Definition

IV for HTN and cardiac dysrythmias

 

Short DOA

Term
Alpha and beta adrenergic blockers
Definition

carvedilol

labetalol

Term
which alpha and beta blocker has antioxidant properties?
Definition

carvedilol

 

Cardioprotective  in MI!

Term
Labetalol uses
Definition

HTN

 

more potent BB than alpha blocker

(non-selective BB, A1 blocker)

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