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Systems Pharmacology II
Exam 3 Review
19
Biology
Graduate
03/26/2012

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Term
benzo for insomnia
Definition
-preg x
-cyp3a4
-Flurazepam
-Temazepam
-Triazolam
Term
benzo rec agonists
Definition
-preg c
-cyp3a4
-Zolpidem
-Zaleplon (fast)
-Eszopiclone (long)
Term
ramelteon
Definition
-binds M1 and M2
-preg c
-cyp1a2
-fast
Term
fast onset
Definition
-clorazepate
-diazepam
-flurazepam
-triazolam
Term
slow onset
Definition
-oxazepam
-prazepam
-temazepam
Term
short half life
Definition
-oxazepam
-triazolam
Term
interm half life
Definition
-alprazolam
-lorazepam
-temazepam
Term
typical
Definition
-phenothiazines (aliphatic, piperidine, piperizine)
-low potency high SE
Term
chlorpromazine
Definition
-aliphatic
-low potency high SE
-D2 M1
Term
thioridazine
Definition
-piperidine
-cardiotoxicity
-D2 M1
Term
Fluphenazine
Definition
-piperizine (high potency high EPS)
-D2
-IM
Term
Trifluoperazine
Definition
-piperizine (high potency high EPS)
-D2
Term
Prochlorperazine
Definition
-piperizine (high potency high EPS)
-D2
-CTZ block
Term
Atypical
Definition
-butyrophenones (high potency, high EPS)
-Heterocyclics
Term
haloperidol
Definition
-butyrophenones (high potency high EPS)
-meperidine
-d2>d1=d4>alpha1>serotonin
Term
heterocyclics
Definition
clozapine
olanzapine
risperidone
Term
clozapine
Definition
-d4, 5-HT2A, H1
-weight gain, seizures, agranulocytosis
-CYP1A2
Term
Olanzapine
Definition
-5-HT2A/2C, D1-D4
-weight gain
-sedation/oHT
-prevent psychosis (off label)
-CYP1A2
Term
risperidone
Definition
-5-HT
-low dose less than 8mg
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