Term
| Parkinson's Disease is an aka for.... |
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Definition
| Parkinson's Disease/PD aka Paralysis Agitans |
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Term
| What is the age of usual onset of PD? |
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Definition
Usual onset after age 50
*affects 1% of the N. American population over 65* |
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Term
| When will onset be involved as a genetic component (what age)? |
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Definition
| Onset under 45 may have a genetic component. |
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Term
Complete the sentence:
Symptoms tend to appear after an ..... decline in dopamine availability. |
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Definition
| Symptoms tend to appear after an 80% decline in dopamine availability. |
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Term
| Which neurotransmitter is insufficient in PD? |
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Definition
PD = dopamine insufficiency
*main neurotransmitter/NT used by the BG* |
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Term
| What do you call abnormalities found in the neurons, typical of PD? |
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Definition
| Lewy bodies : abnormalities found in the neurons in PD |
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Term
| Which cells, responsible for the BG dopamine supply, degenerate in PD? |
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Definition
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Term
| How many GB dysfunctions need to be present in order to diagnose someone with Parkinson's disease? |
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Definition
| Dx based on presence of 3 or more 1o BG dysfunctions. |
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Term
Name the 2o soft tissue changes common and compromising function and comfort in PD.
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Definition
> contracture
> compression syndromes
> arthritic changes |
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Term
True or false?
PD does not have insomnia associated with the condition. |
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Definition
False
Insomnia and other sleep disorders may be present. |
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Term
Complete the sentence:
Alzheimer's like dementia is seen in .....% of individuals with PD. |
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Definition
Alzheimer's like dementia is seen in 15-20% of individuals with PD.
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Term
| Which dopamine precursor was known to get 1-3% across the BBB (however with major side effects)? |
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Definition
Levodopa
*forms of dopamine are still not able to cross the blood-brain barrier* |
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Term
| What medication is used to slow the metabolic breakdown of dopamine in patients with Parkinsonism? |
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Definition
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Term
Complete the sentence
Parkisonian syndromes reflect patterns of damage to one or more ...... |
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Definition
Parkisonian syndromes reflect patterns of damage to one or more basal nuclei. |
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Term
| Name a drug that may block dopamine receptors. |
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Definition
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