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TCN Lesson 9: The Endocrine System
The College Network Anatomy and Physiology Endocrine System Terms
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04/15/2012

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Term
absorptive state
Definition
after a meal the period during which the body receives nutrients from food in the intestine
Term
Addison's syndrome
Definition
A condition in which the supply of adrenal steroids is inadequate, either due to damage to the adrenals themselves or to failure of ACTH secretion
Term
adenohypophysis
Definition
the anterior lobe of the pituitary gland that secretes six glycoprotein hormones
Term
adenyl cyclase
Definition
converts a small fraction of the cell's supply of ATP into cAMP
Term
adrenal medulla
Definition
a branch of the sympathetic nervous system that secretes catecholamines, epinephrine and norepinephrine
Term
adrenalin
Definition
the catecholamine epinephrine
Term
adrenogenital syndrome
Definition
excess androgen that masculizes the genitalia of female fetuses if the mother has the defect
Term
aldosterone
Definition
an adrenal cortical steroid that plays an important role in regulating both Na+ content, and with ADH, extracellular fluid volume
Term
alkalosis
Definition
excessive plasma alkalinity
Term
angiotensin I
Definition
Converts to angiotensis II by angiotensis-converting enzyme (ACE)
Term
angiotensinogen
Definition
a plasma protein that splits off angiotensin I when renin acts on it
Term
anterior lobe
Definition
the adenhypophysis or pars distalis
Term
antidiuretic hormone
Definition
Also known as vasopressin, ADH increases the rate of recovery of water from collecting ducts in the kidney; thus it promotes water conservation and the production of scanty, concentrated urine
Term
arachidonic acid
Definition
a fatty acid present in plasma membranes
Term
atrial natriuretic factor (ANF)
Definition
a peptide hormone released by the muscle fibers of the atria, that along with ADH and aldosterone, regulates kidney function
Term
basal metabolic rate (BMR)
Definition
The rate of energy use that is unrelated to specific body activities such as eating, exercise, or keeping warm
Term
calcitonin
Definition
a hormone secreted by the thyroid that stimulates bone calcification
Term
calcium ion (Ca++)
Definition
An important second messenger involved in activating secretion in exocrine and endocrine glands
Term
calmodulin
Definition
The major Ca++ binding protein for smooth muscle and nonmuscle cells
Term
Carrier proteins
Definition
specific proteins that carry steroid hormones in the blood as complexes
Term
cell-surface receptors
Definition
hormones are recognized by these membrane-spanning receptors that then generate an intracellular second messenger
Term
cholecystokinin (CCK)
Definition
inhibits gastric emptying, and stimulates gall bladder contractions to increase delivery of digestive enzymes to duodenum.
Term
colloid
Definition
a protein matrix that acts as a reservoir for iodine accumulated in the thyroid from the blood
Term
Cushing's syndrome
Definition
a condition in which excessive adrenal activity is generally the result of excessive secretion of ACTH
Term
cyclic adenosine monophosphate (cAMP)
Definition
the cyclic nuceotide that acts as a second messenger
Term
diabetes mellitus
Definition
failure of the pancreas to secrete adequate insulin
Term
diacylglycerol
Definition
a signaling substance that is a hydrophobic molecule that diffuses freely within the plasma membrane and acts on a specific family of protein kinases (C kinases) distinct from that affected by cyclic nucleotides
Term
dihydrotestosterone
Definition
a gonadal male hormone
Term
duodenum
Definition
Part of the GI tract that secretes a large number of peptide hormones
Term
endocrine gland
Definition
a structure specialized for production and secretion of hormones
Term
endorphins
Definition
peptide hormones involved in the process by which the body modulates its own pain sensitivity
Term
enkephalins
Definition
peptide hormones involved in the process by which the body modulates its own pain sensitivity
Term
epinephrine
Definition
secreted by the adrenal medulla, a catecholamine that is an important hormone, along with cortisol and glucagon, of the post-absorptive state.
Term
erythropoietin (EPO)
Definition
a hormone that acts on the hematopoietic tissue of flat bones to stimulate the production of red blood cells
Term
estrogens
Definition
the gonadal female sex hormones
Term
exopthalmos
Definition
a protrusion of the eyes due to hyperthyroidism
Term
follicle-stimulating hormone (FSH)
Definition
one of 2 gonadotropins secreted by the adenohypophysis that control gonadal mass and function
Term
gametogenesis
Definition
the formation of reproductive cells
Term
gastrin
Definition
a mediator secreted by the stomach that stimulates secretion of acid and pepsin by the gastric mucosa
Term
glucagon
Definition
secreted by the pancreas, a hormone, along with cortisol and epinephrine, that is important in the post-absorptive state
Term
glucose tolerance test
Definition
a test for the clinical diagnosis of diabetes mellitus in which the patient fasts until the post-absorptive state is reached, then ingests a glucose meal
Term
glucose-dependent insulinotropic hormone (GIP)
Definition
a hormone released in response to the appearance of a carbohydrate meal in the duodenum and stimulates an early release of insulin in advance of the appearance of the glucose in the blood
Term
gonadotropin releasing factor (GNRF)
Definition
secreted by the hypothalamus to control the secretion of luteinizing hormone and follicle-stimulating hormone
Term
hematocrit
Definition
the fraction of blood volume that is red blood cells
Term
human growth hormone (HGH)
Definition
a hormone that plays a central role in the control of growth throughout the body
Term
hypertension
Definition
elevated blood pressure
Term
hypocalcemia
Definition
a drop in plasma Ca++
Term
hypokalemia
Definition
depressed plasma K+
Term
hypothalamopituitary portal system
Definition
a special variety of blood circulation that involves two sets of capillaries connected by one or more portal veins
Term
hypothyroid cretinism
Definition
a form of mental retardation caused by early thyroid deficiency
Term
hypovolemia
Definition
a decrease in the volume of the circulating blood
Term
islets of Langerhans
Definition
endocrine cells embedded in the exocrine tissue that secrete three major protein hormones: glucagon, insulin and somatostatin
Term
leptin
Definition
a protein hormone released by adipose cells in proportion to their stored fat content that acts on the CNS to suppress appetite
Term
luteinizing hormone (LH)
Definition
one of the two gonadotropins secreted by the adenohypophysis that control gonadal mass and function
Term
melanocyte-stimulating hormones
Definition
a family of hormones included in the POMC sequence that are important in animals that change color, but apparently have no normal function in humans.
Term
melatonin
Definition
a hormone secreted by the pineal gland that plays an important role in synchronizing the 24 hour cycle of the body and promoting rest during darkness
Term
motilin
Definition
a hormone that stimulates periodic waves of contraction in the post-absorptive gut, which we identify as "stomach growling"
Term
myxedema
Definition
a disorder of body fluid distribution caused by excessive production of mucopolysaccharides in tissues
Term
neurohypophysis
Definition
an extension of the hypothalamus that contains the axon terminals of neurosecretory hypothalamic neurons
Term
neurosecretory cells
Definition
neurons whose synapses release substances that pass into the blood and act as hormones
Term
noradrenalin
Definition
the catecholamine norepinephrine
Term
norepinephrine
Definition
the major transmitter chemical released by sympathetic postganglionic fibers
Term
nuclear receptor
Definition
structure within the cell that interacts with mainly steroid hormones
Term
oxytocin
Definition
the octapeptide hormone primarily associated with labor and breast-feeding
Term
parathormone (PTH)
Definition
the hormone of the parathyroids that regulates bone growth and plasma Ca++ levels
Term
paraventricular nucleus
Definition
releases the octapeptide hormone oxytocin
Term
peptide
Definition
a small protein that may range from as few as three amino acids to about thirty amino acids
Term
phosphodiesterase
Definition
an enzyme that converts cAMP to an inactive form
Term
phospholipase C
Definition
a membrane-bound enzyme that splits a small fraction of the plasma membrane's phospholipid (phosphoinositol) into two signaling substances: inositol trisphosphate (ITP or IP3) and diacylglycerol
Term
placental lactogen
Definition
a hormone that prepares breasts for lactation and mobilizes maternal nutrients for uptake by fetus
Term
postabsorptive state
Definition
Within a few hours after a meal, the body enters this state in which it is no longer receiving nutrients from food in the intestine and must begin to draw upon its reserves of stored energy
Term
posterior lobe
Definition
the neurohypophysis or pars nervosa of the pituitary gland
Term
posttranslational processing
Definition
a process that snips the pro hormone's sequence at various points to yield the shorter sequences of the various hormones
Term
progestins
Definition
gonadal female sex hormones
Term
prohormone
Definition
a physiologically inactive precursor of a hormone
Term
prolactin (PRL)
Definition
a hormone that has a critical role in sustaining milk production and in inhibiting reproduction cycling during lactation
Term
proopiomelanocortican
Definition
a protein sequence in which the primary transcript of the gene is translated and serves as a prohormone
Term
prostaglandin
Definition
the major class of eicosanoids that are key mediators in the control of blood flow and inflammation
Term
protein kinases
Definition
activated kinases attach phosphate groups to intracellular enzymes, activating (or inhibiting) them - an example of allosteric regulation
Term
renal erythropoietic factor
Definition
a factor released when the kidney experiences an inadequate supply of oxygen that stimulates the synthesis of the hormone erythropoietin
Term
renin
Definition
an enzyme secreted by the kidney that is a proteas that acts on angiotensinogen to split off angiotensin I
Term
second messenger
Definition
relays a hormone's effect to molecules and structures inside the cell, amplifying the effect of one hormone binding event by acting on several intracellular targets
Term
secretin
Definition
a hormone that inhibits gastric acid secretion, stimulates alkali secretion by exocrine pancreas
Term
sella turcica
Definition
the pocket in the sphenoid bone that encloses the pituitary gland
Term
somatostatin
Definition
a somatotropin release-inhibiting factor that also serves as a GI tract hormone
Term
somatotropin
Definition
a growth hormone
Term
targets
Definition
a limited subset of body tissues affected by a given hormone
Term
testosterone
Definition
a gonadal male hormone
Term
tetraiodothyronine (T4)
Definition
a thyroid hormone that has four (T4) atoms of iodine bound to the two benzene rings of each hormone molecule
Term
thyroid follicles
Definition
millions compose the thyroid gland. Each follicle consists of a single layer of cuboidal epithelial cells surrounding a central space filled with colloid
Term
thyroxine
Definition
one of the two main hormones secreted by the thyroid
Term
triiodothyronine (T3)
Definition
a thyroid hormone that has three (T3) atoms of iodine bound to the two benzene rings of each hormone molecule
Term
tropic hormones
Definition
hormones that control the function of other endocrine glands
Term
troponin
Definition
the Ca++ binding protein in skeletal and cardiac muscle
Term
tyrosine
Definition
an aromatic amino acid from which the catecholamines epinephrine and norepinephrine and the thyroid hormones triiodothyronine (T3) and tetraiodothyronine (T4) are derived
Term
vasopressin
Definition
an antidiuretic hormone
Term
Sequence of events that occurs in a hormonal response mediated by a cyclic nucleotide second messenger
Definition
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