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Teratogens
First Aid 2012 p127
19
Medical
Graduate
01/13/2013

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Cards

Term
ACE inhibtiors
Definition
renal damage
Term
alkylating agents
Definition
absence of digits, multiple anomalies
Term
aminoglycosides
Definition
CN VIII toxicity
Term
carbamazepine
Definition
neural tube defects, craniofacial defects, fingernail hypoplasia, developmental delay, IUGR
Term
diethylstilbestrol (DES)
Definition
vaginal clear cell adenocarcinoma
Term
folate antagonists
Definition
neural tube defects
Term
lithium
Definition
Ebstein's anomaly
Term
phenytoin
Definition
fetal hydantoin syndrome -- microcephaly, dysmorphic craniofacial features, hypoplastic nails and distal phalanges, cardiac defects, IUGR, MR
Term
tetracyclines
Definition
discolored teeth
Term
thalidomide
Definition
limb defects ('flipper" limbs)
Term
valproate
Definition
neural tube defects (inhibits maternal folate absorption)
Term
warfarin
Definition
bone deformities, fetal hemorrhage, abortion, ophthalmologic abnormalities
Term
alcohol
Definition
fetal alcohol syndrome
Term
cocaine
Definition
abnormal fetal development and fetal addiction; placental abruption
Term
smoking
Definition
preterm labor, placental problems, IUGR, ADHD
Term
iodidie (lack or excess)
Definition
congental goiter or hyperthyroidism
Term
maternal diabetes
Definition
caudal regression syndrome (anal atresia to sirenomelia), congenital heart defects, neural tube defects
Term
vitamin A (excess)
Definition
extremely high rick for spontaneous abortions and birth defects (cleft palate, cardiac abnormalities)
Term
x-rays
Definition
microcephaly, MR
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