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The Mechanism of Anaphylaxis: Second Exposure
process
5
Anatomy
Undergraduate 1
10/31/2012

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Cards

Term
start of second exposure
Definition
b cell has IgE antibodies on its surface that detect allergen
Term
b cell has IgE antibodies on its surface that detect allergen

what happens next?
Definition
Sensitization of mast cells and basophils

(aka they get to meet the antigen)
Term
Sensitization of mast cells and basophils

what happens next?
Definition
Massive stimulation of mast cells and basophils

(both cause inflammation)
Term
Massive stimulation of mast cells and basophils

what comes after this
Definition
Release of histamines, leukotrienes, and other chemicals that cause pain and inflammation
Term
Release of histamines, leukotrienes, and other chemicals that cause pain and inflammation

what comes next?
Definition
Capillary dilation/ increased permeability
airway constriction,
mucus secretion,
pain and itching
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