Shared Flashcard Set

Details

therapeutics test1
DVT/PE
51
Other
Professional
08/27/2013

Additional Other Flashcards

 


 

Cards

Term

VTE PPX options:

-mechanically blocks thrombi from causing PE

-Wont prevent DVT or postthrombotic syndrome

-useful if anticoag is contraindicated

-large venous collateral vessels can dev.

Definition
IVC
Term

VTE PPX options:

prevention of choice

5,000 units SC q8-12hrs

Definition
LDUH
Term

VTE PPX options:

maintain aPTT w/in therapeutic range at midpt of dosing interval

Definition
ADH
Term

VTE PPX options:

 

approved for hip & knee replacement

Definition
Enoxaparin-Lovenox 30mg Sc q12h
Term

VTE PPX options:

 

approved for Hip replacement, abdominal sugery, & gen medical PPX

Definition
Enoxaprin (Lovenox)-40mg SC qd
Term

VTE PPX:

2500 IU SC pre-op and post-op, then 5000 IU SC qd

5000 IU SC qd beginning day before surgery

Definition
Dalteparin-fragmin
Term

VTE PPX options:

approved for VTE PPX after abdominal & hip sugery

Definition
dalteparin-fragmin
Term

VTE PPX options:

approved for DVT PPX for hip & knee replacement & hip fracture surgery

Definition
Fondaparinex-Arixtra 2.5mg SC q6-8h after abdominal sugery, then q24h
Term

VTE PPX options:

dosed to maintain an INR in the range of 2.0-3.0

Definition
warfarin
Term

VTE PPX options:

10mg qd w/out regard to meals beginning at least 6-10hrs after sugery

 

Definition
rivaroxaban (xarelto)
Term

VTE PPX options:

treat THR:35 days

treat TKR:12 days

Definition
rivaroxaban-xarelto
Term
fondaparinux 2.5mg 6-24h after sugery, then qd
Definition
THR
Term
fondaparinux 2.5mg 6-8h after sugery, then qd
Definition
TKR
Term
INR> therapeutic but<4.5 w/ no blding
Definition

lower dose or omit a dose

resume therapy at appropriate dose when INR is therapeutic

if INR only minimally greater than therapeutic, no dose reduction may be required

Term
INR≥4.5 but < 10, no sig blding
Definition

omit 1-2 doses

monitor INR more freq, and resume therapy at an approp dose when INR therapeutic

Term
INR>10 w/ no evidence of blding
Definition

omit dose

oral vit k 5mg

indiv treatment approach

Term
serious blding risk at any elevated INR
Definition

omit warfarin dose

4 factor prothrombin complex concentrate

vit K 10mg IV slow infusion/20min(q12h prn persistent INR elevation)

fresh frozen plasma

recomb factor VIIa

Term
Phytonadione (Vit K) for INr reversal- Oral
Definition

preferrred when no active blding

1.4 day av for INR 6-10 to decline <4

ava as 5mg tab

Term
SNP
Definition

gold std for hypertensive encephalopathy

 

Term
SNP
Definition

arterial and venous dilator

lowers BP w/in 1-2 min

doesnt apear to signif compromise CBF

Term
SNP
Definition

↓ preload, afterload, and myocardial oxygen demand

↑ pulmonary shunting "coronary steal"

onset: w/in sec t1/2: 1-2 min

Term
SNP dose:
Definition
0.25 mcg/kg/min~10 mcg/kg/min
Term
IV NTG
Definition
treatment of choice for coronary ischemia
Term
nicardipine
Definition
used for: most indications, postop HTN, HTN w/ inc intercranial press
Term
SE of IV NTG
Definition
methemoglobinemia
Term
most common IV CCB
Definition
nicardipine
Term
nicardipine uses:
Definition
most indications, postop HTN, HTN w/ increase intrscranial press
Term
nicardipine SE:
Definition
overshoot has offset & phelbitis
Term
3rd gen CCB, ultrashort selective arteriolar vasodilator
Definition
Clevidipine
Term
Clevidipine SE:
Definition
allergy to eggs/soy & hypertriglyceridemia
Term
selective Beta1 adren R antagonist
Definition
esmolol
Term
esmolol used for:
Definition
aortic dissection and periop HTN and to control certain supraventricular arrythmias
Term
esmolol SE:
Definition
heart block, HF, asthma, hypotension
Term
agonist of dopamine D1 R
Definition
fenoldopam
Term
fenoldopam used for:
Definition
DOC in HTN renal dis
Term
fenoldopam CI:
Definition
pt w/ glaucoma
Term
selec alpha1 and nonselc Beta R antagonist
Definition
labetaolol
Term
labetalol for:
Definition

DOC for

stroke/aortic dissection does not reduce CBF  

excess catecholamine, such as pheochromocytoma or clonidine w/drawal

prego

Term
labetalol is second line for:
Definition
HTN encephalopathy
Term
labetolol disadv
Definition

unpred dose reponse

may worsen CHF

in pheochromocytoma may induce paradoxical rise in BP

Term
labetaolol SE:
Definition
scalp tingling, bronchocontriction heart block
Term
active metabolites (post-drug) of enalapril
Definition
enalaprilat
Term
enalaprilat used for
Definition
for prevention or management of postop HTN pt perviously treated w/ ACEI
Term
Enalaprilat disadv
Definition

precipitous fall in BP in high renin states

variable response

NOT DOC AMI or renal failure

Term
direct vasodilating agent (arterioles)
Definition
hydralazine
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