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thrombotic
harpell lecture thrombotic disroders
9
Medical
Graduate
09/04/2011

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Term
virchows triad
Definition
hypercoagulability, stasis, vesse l wall injury , all three ened to be present for thrombosis to occur.
Term
large vessel clotting risk
Definition
more likely toh appen because anticlotting factors get removed the the endothelial wall, where blodo is moving slowly, in center blod osi movign fast so normally not ap roblem but increased stasis will cause clotting.
Term
venous thromboembollism
Definition
dvt plus pe
Term
dvt on national stage
Definition
though is one ofh te biggest cause of deaths in the nation, many may be prventable.
Term
circulatory stasis
Definition
atrial fibrillation. Left ventricular dysfuncion, immobility , venosu inssuficeincy, varicose veins. Venous bostrumction form tumor obsesity orp regnancy.
Term
vascular waall injury causes
Definition
trauma, venepuncture, chemical irritation, heart valve disease/replacement, atherosclerosis,indwellign catheters.
Term
hyperocauble state
Definition
malignancy, pregnancy (because need to prepare or massive blood loss of pregnancy, trauma or surger of lower extremity, inflammatory bowel disease, nephrotic syndrome (lose anticoagulant rpoteins), sepsis, thrombophilia
Term
when should we test
Definition
if unsuual patient, someone who souldnth ave acquired thrombotic isks do thromphoiliat esting. IF thrombophilia unlikely nad thrombosis of known cause give 3 months of anticoag. Otherwise give 6 months . Best time for testing is six months after thrombotic event when treatmetn has stopped, thrombosis itself messes up native factorelevels.
Term
when to conitnue teratment
Definition
if of known cuaseand is fixed don’t need to conitneu treatment, if it occurred again should be put back on therapy, if have thormboophiilia should stay on therapy, if life therattening event, should stay on.
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