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Tissue Healing
Tissue Healing
128
Medical
Graduate
01/25/2016

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Term
Primary injuries are defined as what
Definition
injuries that are self-inflicted, caused by another individual or entity, or caused by the environment
Term
Primary injuries are split into what 3 categories
Definition
acute
chronic
acute on chronic
Term
what is an acute on chronic injury?
Definition
acute flare up of a chronic injury
Term
Secondary injuries are defined as what
Definition
inflammatory response that occurs with the primary injury
Term
Healing abnormalities can be be d/t complicaitons such as (3)
Definition
infection
compromised circulation
neuropathy
Term
3 main phases of wound healing
Definition
inflammatory
proliferative
remodeling
Term
2 reactions within the inflammatory phase
Definition
coagulation
inflammation
Term
main funcitons of exudate during the inflammatory phase (3)
Definition
provide cells capable of tissue reconstruction
dilute microbial toxins
remove contaminatns present in the wound
Term
Inflammation is mediated by what substances
Definition
chemotactic substances including anaphylatoxins
Term
role of anaphylaxtonxins during the inflammatory phase (2)
Definition
attract neutrophils and monocytes
Term
white bloods cells that bind to microorganisms, internalize them, and kill them
Definition
Neutrophils
Term
white blood cells that develop into macrophages, and provide immunological defesnes against many infectious organisms
Definition
monocytes
Term
what marks the end of the inflammatory process
Definition
complete removal of the wound debris
Term
how long can the inflammatory phase last
Definition
1-6 days, longer than 6 months
Term
Common causes for a persistent chronic inflammatory response include (8)
Definition
infectious agents
persistent viruses
hypertrophic scarring
poor blood supply
edema
repeated direct trauma
excessive tension at wound site
hypersensitivity reactions
Term
during the inflammatory phase there is pain when (3)
Definition
at rest
with active motion
when specific stress is applied to the injured structure
Term
if the pain is severe enough during the inflammatory phase what will happen
Definition
loss of function, muscle guarding
Term
if there is constant pain regardless of rest or activity what is going on
Definition
there is an inflammatory process present
Term
characteristic changes of the proliferative phase (3)
Definition
capillary growth
granulation tissue formation
fibroblast formation with collagen synthesis and increased macrophage and cell activity
Term
capillary growth during the proliferative phase includes what (2)
Definition
angiogenesis, neovascularization
Term
how long does the proliferative phase last
Definition
5-15 days, often up to 10 weeks depending on the type of tissue and the damage
Term
remodeling phase of wound healing invovles what
Definition
conversion of the inital healing tissue to scar tissue
Term
how long can the remodeling phase last up to
Definition
up to a year
Term
what collagen is being replaced by what during the remodeling phase
Definition
type 3 collagen being replaced by type I collagen
Term
only tissue in the body to be able to restore itself to its original state after damage
Definition
bone
Term
imbalances in what during the remodeling phase may result in hypertrophic scarring or keloid formation
Definition
imbalances in collagen synthesis and degredation during this phase of healing
Term
why is a scar considered to be non funcitonal
Definition
lack of an elastic component making the scar more brittle and prone to breaking again
Term
if left untreated, how large will a hypertrophic scar or keloid formation be
Definition
less than 20% of its original size
Term
scarring that occurs in what line of force of a structure is less vulnerable to re-injury
Definition
parallel to the line of force
Term
Muscle injury can result from (6)
Definition
excessive strain
contusions
excessive tension
lacerations
thermal stress
myotoxic agents
Term
injury which accounts for 90% of muscle tissue injuries
Definition
excessive strain
Term
strain refers to what tissue types
Definition
musculotendinous
Term
sprain refers to what tissue type
Definition
ligaments
Term
myotoxic agents which cause mm injury (4)
Definition
local anesthetics
excessive use of corticosteriods
snake/bee venom
heavy dose antibiotics
Term
factors contributing to injury: (3) inadequate
Definition
flexibility
strength or endurance
rehabilitation from previous injury
Term
factors contributing to injury: insufficient
Definition
warm up
Term
factors contributing to injury: dyssyngergistic
Definition
muscle contraction
Term
what is dyssyngergistic muscle contraction
Definition
abnormal muscle activation
Term
factors contributing to injury: insufficient warm up refers to what
Definition
inappropriate warm up for the actvity to be done
Term
what is a hematoma
Definition
contusion to a muscle belly
Term
2 types of hematomas
Definition
intramuscular
intermuscular
Term
intramuscular hematomas are associated with what injury (2)
Definition
muscle strain
bruise
Term
which hematoma's size is limited by the muscle fascia
Definition
intramuscular
Term
what is an intramuscular hematoma
Definition
if the mm fascia is ruptured and the extravasated blood spreads into the interfascial and interstistal spaces
Term
contraindication for PT therapy with hematomas
Definition
no deep heat
Term
secondary condition as a result of a hematoma
Definition
myositis ossificans
Term
muscle strains grades
Definition
1-3
Term
Describe a Grade I Muscle Strain
Definition
a tear of a few muscle fibers with minor swelling and discomfort
associated with no or minimal loss of strength and restriction of mvmt
strong and painful
2-4 weeks for healing
Term
Describe a Grade II Muscle Strain
Definition
Greater damage of teh muscle and clear loss of strength and some loss of function
Weak and Painful
4-6/8 weeks healing
Term
Describe a Grade 3 muscle strains
Definition
tear extending across the whole muscle belly
characterized by severe pain or loss of function
presence of palpable and/or observable deformity
weak and painless
Term
the capacity of muscle for regeneration is based primarily upon what (3)
Definition
type of injury
extent of injury
location of injury
Term
3 healing phases in the healing process of an injured mm
Definition
destruction phase
repair phase
remodeling phase
Term
what should the guiding factor be in treatment of a muscle injury
Definition
pain
Term
principles for mgmt of mm injury: best course of treatment for muscle injury
Definition
controlled mobility and activity
Term
what is a ligament
Definition
fibrous band of dense connective tissue that connnects bone to bone and which behave as a viscoelastic structures when exposed to stress
Term
ligament injuries are referred to as what
Definition
sprain
Term
how many grades of sprains are tehre
Definition
3
Term
Describe a Grade I sprain
Definition
painful, but do not have swelling or instability
Term
Describe a Grade II sprain
Definition
marked swelling and pain
mild ligament laxity and jt instability
Term
Describe a Grade III sprain
Definition
complete disruption of the ligament with gross instability and laxity
Term
Ligament healing is dependent on what (4) factors
Definition
anatomic location
presence of associated injuries
vascularity
function of the ligament
Term
difference between extraarticular and intra-articular ligament injuries
Definition
extra-articular ligament tears that are comlete tears can heal together if they are immobilized correctly.
Intra-articular ligament tears will not
Term
Intraarticular ligament tears are limited by what
Definition
vascularity and synovial fluid which may hinder inflammatory phase
Term
4 phases of extra-articular ligament healing
Definition
hemorrhagic
inflammatory
proliferation
remodeling and maturation
Term
early intervention for ligament injury
Definition
early excercised ligaments stronger than those that are immobilized
Term
interventions for ligament injury: minimize what
Definition
periods of immobilization
Term
interventions for ligament injury: progressively...
Definition
stress while exercising caution relative to biomechanical considerations
Term
interventions for ligament injury: purose of low cyclical loads
Definition
promotes scar proliferation adn material remodeling making scar stronger and stiffer
Term
tendinitis implies what type of reaction
Definition
an inflammatory reaction to a tendon injury
Term
the term tendinitis implies an inflammatory reaction to a tendon injury, a microscopic tearing and inflammation of the tendon tissue commonly resulting from what
Definition
tissue fatigue rather than direct trauma
Term
How many grades of tendinitis
Definition
5
Term
Describe Grade I Tendinitis
Definition
pain after activity
does not interfere with performance
generalized tenderness
resolves before next exercise session
Term
Describe Grade II Tendinitis
Definition
Minimal pain with activity
Does not interfere with activity
Local tenderness
Term
Describe Grade III Tendinitis
Definition
pain limits activity
disappears between sessions
Term
Describe Grade IV Tendinitis
Definition
pain remains and seriously interferes with training
Pain, tenderness, crepitus, and swelling may be present
Term
Describe Grade V Tendinitis
Definition
pain interferes with sports and ADLs
symtoms chronic or recurrent
Signs of tissue changes and altered muscle function
Term
is crepitus normal?
Definition
no, but as long as it isn't painful its "okay"
Term
Grade IV, and V tendinitis tend to become more what
Definition
tendinosis (degenerative changes) rather than tendinitis (inflammatory)
Term
Inflammatory disorder of tissues surrounding the tendon such as the tendon sheath, usually the result of a repetitive friction of the tendon and its sheath (3)
Definition
tenosynovitis
peritendinitis
paratenotitis
Term
example condition of tenosynovitis
Definition
dequervains
Term
paretenonitis is common to what large tendon
Definition
achilles
Term
tendinosis refers to what
Definition
degenerative process of teh tendons
Term
tendinosis is characterized by the presence of what (3)
Definition
presence of dense populations of fibroblasts
vascular hyperplasia
disorganized collagen/angiofibroplastic hyperlasia
Term
in tendinosis there is an absence of what cells
Definition
inflammatory cells
Term
tendinosis typical clinical finding
Definition
strong and painful
Term
mechanism for pain generation for tendinosis
Definition
unclear
Term
general term encompassing all tendon pathology types
Definition
tendinopathy
Term
healign of ligaments and tendons can be broken down into ____ overlapping phases
Definition
4
Term
what are the 4 overlaping phases of tendon/ligament healing
Definition
Hemoorhagic
Inflammatory
Proliferation
Remodling and maturation
Term
mgmt of tendonitis vs tendinosis: key to therapy for both
Definition
judicious application of force to encourage new collagen fibril alignment in directino of force is key
Term
mgmt of tendonitis vs tendinosis: key consideration for tendonitis
Definition
inflammation
Term
mgmt of tendonitis vs tendinosis: key consideration in tendinosis rehab
Definition
loading based rehab
Term
recommended tx for chornic tendinopathy
Definition
eccentric based
Term
viscoelastic structure with a very high tensile strength and is resistant to compressive and shearing forces
Definition
articular cartilage
Term
Arthroscopic Grading System for Cartilage Defects was made by who
Definition
International Cartilage Repair Society
Term
Arthroscopic Grading System for Cartilage Defects: how many grades
Definition
5
Term
Arthroscopic Grading System for Cartilage Defects: Grade 0
Definition
normal healthy cartilage
Term
Arthroscopic Grading System for Cartilage Defects: Grade 1
Definition
cartilage has a soft spot or blisters
Term
Arthroscopic Grading System for Cartilage Defects: Grade 2
Definition
minor tears visible in the cartilage
Term
Arthroscopic Grading System for Cartilage Defects: Grade 3
Definition
lesions have deep crevices (more than 50% of cartilage layer)
Term
Arthroscopic Grading System for Cartilage Defects: Grade 4
Definition
cartilage tera exposes the underlying (subchondral bone)
Term
Articular cartilage healing/treatment
Definition
capacity of articular cartialge for repair is limited
Term
INjuries of the articular cartilage that do not penetrate the subchondral bone become what
Definition
necrotic and do not heal
Term
injuries of the articular cartilage that do not penetrate the subchondral bone become necrotic and do not heal and usually progress to what
Definition
the degeneration of the articular surface
Term
why do articular cartilage injuries that penetrate the subchondral bone undergo repair?
Definition
d/t access to the bone's blood supply
Term
articular cartilage injuries that penetrate the subchondral bone and are repaired are usually characterized as (3)
Definition
fibrous
fibrocartilaginous
hyaline-like cartilaginous
Term
what is yaluronic acid
Definition
man mande synovial fluid
Term
mgmt of cartilage injury: viscosupplemenation
Definition
intra-articular injections of hyaluronic acid
Term
mgmt of cartilage injury: supplementation
Definition
glucosamine and chondroitin
Term
mgmt of cartilage injury: surgical interventions (4)
Definition
arthroscopic debridement
microfracture
autologus chondrocyte cell implantation
mosaiplasty
Term
mgmt of cartilage injury: what is more effective than arthroscopy for DJD of the knee
Definition
PT with frequent controlled exercise
Term
bone is better able to withstand _____ forces rather than _____ or ______ forces
Definition
compressive
tensile
torsional
Term
if the adaptations of bone to stress do not occur fast enough, what happens to the bone
Definition
the bone is resorbed faster than it is replaced and bone strength is compromised
Term
If the adaptations of bone to stress do not occur fast enough, the bone is resorbed faster than it is replaced. Causes of decreased adaptation include (3)
Definition
increase in the applied load
increase in the number of applied stresses
decrease in the size of the surface area over which the load is applied
Term
the striking feature of bone healing, compared to healing, is that repair is by _____ ______ not scar tissue
Definition
original tissue
Term
Bone healing inolves a combination of ______ and _______ ossification
Definition
intramembranous
endochondral
Term
2 broad phases of bone fracture healing
Definition
primary fracture healing
secondary fracture healing
Term
primary bone healing involves what
Definition
a direct attempt by the cortex to reestablish itself once it has become interrupted
Term
Secondary bone healing involves what
Definition
responses in the periosteum and external soft tissues with the subsequent formation of a callus
Term
the majority of fractures heal by what type of fracture healing
Definition
secondary fracture healing
Term
Immobilization: effects on cartilage
Definition
cartilage degeneration
Term
Immobilization: effect on ligaments
Definition
decrease in the mechanical and structural properties of ligaments
Term
Immobilization: effect on bone
Definition
decrease in bone density
Term
Immobilization: effect on muscles
Definition
weakness or atrophy of muscles
Term
PT Rx of Ex to Promote Tissue Repair: Tendon Protocol
Definition
controlled loading of tendon after injury enhanced tissue healing
Term
PT Rx of Ex to Promote Tissue Repair: muscle protocol
Definition
after a brief period of scar formation and stabilization, controlled loading improved regeneration of myotubes and prevented atrophy of surrounding tissue
Term
PT Rx of Ex to Promote Tissue Repair: articular cartilage protocol
Definition
application of CPM (continuous passive machine) following cartilage transplant enhanced patient outcomes
Term
PT Rx of Ex to Promote Tissue Repair: Bone protocol
Definition
addition of cyclical compressive loading to healing bone tissue enhanced patient strength and ROM following immobilization periods
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