Term
| Bone marrow failure is unlikely to be associated with: |
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Definition
| Reticulocytosis - failure of bone marrow to produce blood elements |
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Term
| Patients who have bone marrow stem cell cancer are prepared for hematopoietic stem cell transplant |
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Definition
| chemotherapy and radiotherapy |
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Term
| What is a source of hematopoietic stem cells? |
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Definition
-blood
-bone marrow
-cord blood |
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Term
| Ideal donor of hematopoietic stem cell transplant is |
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Definition
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Term
| Hematopoietic stem cells are given to recipient by... |
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Definition
| infusing cells into the patients blood |
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Term
| Patients who have bone marrow stem cell cancer are prepared for a hematopoietic stem cell transplant by... |
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Definition
| Chemotherapy and radiotherapy |
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Term
| What are some complications of stem cell tansfer |
|
Definition
-cancer
-failure of the graft to survive
-GVHD
-infection |
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Term
| The cells infiltrating target tissues in chronic graft versus host disease are... |
|
Definition
| mixtures of monoclonal cells of donor and recipient origin |
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Term
| Survival of a hematopoietic stem cell transplant and its establishment in the bone marrow maybe determined by... |
|
Definition
| complete blood cell counts |
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Term
| In the weeks following hematopoietic cell transplantation most patients require... |
|
Definition
| red blood cell transfusions |
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Term
| A risk with being a hematopoietic stem cell donor is... |
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Definition
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Term
A patient with aplastic anemia is given a hematopoietic stem cell transplant from a matched but unrelated bone marrow donor.
At 35 days the transplant exhibits GVHD. List one way this could have been prevented. |
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Definition
| Elimination of T lymphocytes from the donor bone marrow |
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Term
| A major drawback of the depletion of T cells from a preparation of allogeneic stem cells to be transplanted to a leukemic patient is... |
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Definition
| Elimination of graft versus leukemia effect |
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Term
Patients who receive hematopoietic stem cell transplants from unrelated donors are frequently treated prophylactically with an immunosuppressive drug such as cyclosporin.
The basis of giving an immunosuppressive drug to a patient whose immune system has been suppressed by chemotherapy and total body irradiation is that cyclosporin administration... |
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Definition
| minimizes or prevents the development of GVDH |
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Term
| An early indication that a hematopoietic stem cell transplant has been successful is... |
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Definition
| An increase in the number of differentiated leukocytes in the blood of the patient a few weeks after the transplant |
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Term
| Biopsy of a skin rash site and the gut wall epithelium in a patient who has received a hematopoietic stem cell transplant is used to confirm the diagnosis of graft-versus-host disease. The presence of mononuclear cell infiltrates in the skin and in the gut epithelium indicates that graft-versus-host disease is: |
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Definition
| a cell-mediated immune reaction |
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Term
| Which one of the following organ or tissue transplants are LEAST likely to cause a graft-vs.-host reaction? |
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Definition
|
|
Term
| Which of the following is least likely to be a complication of hematopoietic stem cell transplantation: |
|
Definition
Autoimmune hemolytic anemia
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Term
Which of the following determinations will give better information about the achievement of immunological reconstitution after stem cell or bone marrow transplant?
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|
Definition
| Significant antibody response after immunization with tetanus toxoid |
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Term
| Mice without a thymus (e.g. no T cells) are transplanted with bone marrow from genetically unrelated and immunocompetent mice. Identify in the following chart the most likely combination of results seen in the grafted mice. |
|
Definition
| Accepted splenomegaly, diarrhea, wasting |
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Term
| Which of the following membrane markers is the basis for the separation of human stem cells from bone marrow? |
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Definition
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Term
| What is the significance of detecting the Philadelphia chromosome? |
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Definition
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Term
| What do you conclude from the HLA data from the family? Discuss the selection of a donor from these family members. |
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Definition
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|
Term
| Which one of the unrelated donors would you select for this patient and why? |
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Definition
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Term
| Discuss how can stem cells be separated from the donor's bone marrow or peripheral blood leukocyte preparation. |
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Definition
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Term
| Discuss the medication management for the patient. For example: What antibiotic(s) is(are) indicated in this patient at the time he develops fever? What antibiotic(s) is(are) indicated in this patient at the time of discharge? Why is this patient given IVIg and cyclosporine? |
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Definition
| The IVIG provides passive immunity for infections that the patient would be inclined to get. |
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