Term
|
Definition
first line
max dose = 4g/day (3g/day in older pts)
hepatic toxicity
caution with alcohol use |
|
|
Term
|
Definition
when acetaminophen ineffective or with sings of inflammation
more toxicity - GI, renal, CV |
|
|
Term
|
Definition
acts on opioid and serotonin pathways
nonulcergonic
can been added to NSAIDs, acetaminophen
SE - nausea, vom, dec seizure threshold, rash, constipation, drowsiness, dizziness |
|
|
Term
|
Definition
topical
counter irritant - enhances Substance P release, cuases desensitization
SE - local burning |
|
|
Term
|
Definition
|
|
Term
|
Definition
most often used in knees, lasts up to 3 mo
with freq injection - risk of infection, worsening diabetes, CHF |
|
|
Term
|
Definition
expensive
requires series of injections
usually used in knee
usually takes 1 month to see benefit |
|
|
Term
| Glucosamine sulfate + chondroitin |
|
Definition
component of ECM macromolecules, present in cartilage and synovial fluid
effect size much less in non-industry funded trials, so no longer recommended |
|
|
Term
|
Definition
~3 million adults in US use for tx of chronic pain, most frequently associated with OA
superior to sham control - shown in metaanalyses |
|
|
Term
|
Definition
physical and mental benefit
may provide ideal form of exercise for older adults with knee OW |
|
|
Term
|
Definition
|
|
Term
|
Definition
transfers load from damaged to undamaged compartments - for use in unicompartmental knee OA
may delay need for TKR for several years
consider in younger pts |
|
|
Term
| Arthroplasty (joint replacement) |
|
Definition
severe pain, sig limited function
esp good for hip and knee
total vs. partial |
|
|
Term
| Arthrodesis (joint fusion) |
|
Definition
| trapeziometacarpal (1st CMC joint) |
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|
