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fatty acid ox acetyl a prodn krebs cycle ETC |
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glycolysis fatty acid synth HMP shunt protein synth (RER) steroid synth (SER) |
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what MB is in cytoplasm & mt? |
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gluconeogensis urea cycle heme synth |
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fatty acid ox acetyl a prodn krebs cycle ETC |
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glycolysis fatty acid synth HMP shunt protein synth (RER) steroid synth (SER) |
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gluconeogensis urea cycle heme synth |
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what MB is in cytoplasm & mt? |
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2 phosphoanhydride bonds @ 7kcal/mol each |
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38 ATP via malate shuttle 36 ATP via G3P shuttle |
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S-adenosyl methionine regen reqs b12 |
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transfers methyl groups to stuff |
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ATP + methionine transfers methyl groups to stuff regen reqs b12 |
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glutamate -> what sign mol? |
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fru-6-p -> fru 1,6,bisp via PFK 1 |
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bisphosphoglycerate mutase |
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catab to carry reducing equivs as NADH |
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anabol (ster & FA synth) reducing equivsanab processes resp burst p450 |
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NADPH (-> O2 rad) superoxide dismutase(H2O2) myeloperoxidase(HClO.)catalase(conv H2O2) glutathione reductase(regen glutath) G6PD(regen NADPH) |
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found throughout body feedback inh by G6P |
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found mainly in liver higher Km & Vmax phosph excess glucose to sequester as G6P (in liver) not FB inh |
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found throughout body feedback inh by G6P |
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found mainly in liver higher Km & Vmax phosph excess glucose to sequester as G6P (in liver) |
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glu->G6P hexokin/glucokin inh: G6P (h)F6P->F1,6P pfk1 inh:atp&citrate act:AMP,F2,6 PEP->Pyr PK inh:ATP,ala act:F1,6 pyr->acCoA pyrDH inh:ATP,nadh,acCoA |
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F6P->F1,6P inh:atp&citrate act:AMP,F2,6 |
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PEP->pyr inh:ATP,ala act:F1,6 |
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pyr->acCoa inh:ATP,NADH,acCoA |
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hemolytic anemia RBCs=no mthexokin,GPisom,aldolase, triphos isom, phos gly kin, enolase, pyr kin |
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3 enzymes, 5 cofactors pyr + NAD + CoA -> AcCoA + CO2 + NADH actd by exer: up NAD, ADP, Ca |
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pyrophosphate (B1) FAD (b2) NAD(b3) CoA(B5, pantothenate) lipoic acid |
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backup of pyr & ala -> lac acidosis seen in B1 def (alcoholics) neuro defs tx:up ketogenic nutrs (high fat, lys & leu) |
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carries amino groups from mm to liver |
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carries amino groups from mm to liver |
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how many atp needed to go pyr ->glu? |
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alanine (ALT) oxaloacetate (CO2 + ATP, via PC) AcCoA (PDH) lac (LDH, NADH-NAD) |
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why go pyr -> oxaloacetate? |
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1) repl TCA cycle 2)gluconeogen |
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mm: makes lac -> liver liver: lac -> pur (LDH) pyr-> glu (6ATP) send back to mm |
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3NADH, 1 FADH2, 2 CO2, 1 GTP = 12 ATP/AcCoA x2/glu |
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same as PDH b1,b2,b3,b5, lipoic acid |
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