Term
|
Definition
| lecithin-sphingomyelin >2.0 in amn fluid |
|
|
Term
| contents of bronchopulm segment |
|
Definition
3ยบ (segmental) bronchus and 2 aa (bronch & pulm) in center
veins & lymph in border |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| structures perforating diaphragm |
|
Definition
IVC (T8)
esophagus, CNX (T10)
aorta, thoracic duct & azygous vein(T12) |
|
|
Term
|
Definition
|
|
Term
|
Definition
in: ext intercostals, scalene, sternomastoids
out:abs, obls, trans abs, int Ics |
|
|
Term
|
Definition
malformation of TE septum
gagging and cyanosis after feeding
abd distn after crying
reflux gastric contents into lung |
|
|
Term
gagging and cyanosis after feeding
abd distn after crying
reflux gastric contents into lung |
|
Definition
malformation of TE septum
TE fistula |
|
|
Term
|
Definition
def surfactant
premies, DM moms, prolonged IU asphyxia
tx: thyroxine & cortisol -> up surfactant |
|
|
Term
|
Definition
stunted lung dev
congen diaphragm hernia or
bilat renal agenesis -> oligohydramnios (Potter's) |
|
|
Term
| congen neonatal emphysema |
|
Definition
failure of bronch cartilage dev -> overfilled alveoli
cart needed to get air out, not in |
|
|
Term
| failure of bronch cartilage dev |
|
Definition
| congen neonatal emphysema |
|
|
Term
congen diaphragm hernia or
bilat renal agenesis->? |
|
Definition
|
|
Term
|
Definition
ac & chr up vent
up EPO->up hct & hgb (chr hypox)
up 2,3DPG
up mt
up renal excr bicarb (bc resp alk)
chr hypox pulm vasoconstr-> RVH |
|
|
Term
|
Definition
surfactant
PGs
histamine
ACE
kallilrein |
|
|
Term
|
Definition
|
|
Term
|
Definition
ATI->ATII
inact bradykinin
(ACEinh-> cough & angioedema) |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Hgb binding curve shift right |
|
Definition
down O2 binding
unload in tissue
CADET (face right): CO2, Acid/Altitude, DPG, Exercise, Temp |
|
|
Term
| pO2 & pCO2 effect on pulm circ |
|
Definition
| OPPOSITE of sys circ - shift blood to good areas |
|
|
Term
|
Definition
cor pulmonale
JVD, edema, hepatomegaly, eventually RVH -> RVF |
|
|
Term
|
Definition
nl O2, CO2, N2O
gas equilibrates along length of cap
need to up BF to up diffusion |
|
|
Term
|
Definition
O2 in exer, emphy & fibr, CO
gas not equilibrated by time it reaches end of cap |
|
|
Term
|
Definition
perfusion ltd
gas equilibrates along length of cap
need to up BF to up diffusion |
|
|
Term
| O2 in exer, emphy & fibr, CO |
|
Definition
diffusion ltd
gas not equilibrated by time it reaches end of cap |
|
|
Term
| determine phys dead space |
|
Definition
| Vd= Vt x (PaCO2 - PeCO2)/PaCO2 |
|
|
Term
|
Definition
nl=1 (0.8)
apex: V/Q=3 (wasted V)
base: V/Q=0.6(wasted perf)
both V&Q are higher at the base than at the lung |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| blood flow obstr (phys dead space) |
|
|
Term
|
Definition
|
|
Term
|
Definition
V/Q->inf
(phys dead space) |
|
|
Term
|
Definition
90%: bicarb
5%: carbaminoHgb
5%dissolved CO2 |
|
|
Term
|
Definition
| Hgb->Hgb(O2) --> dissoc CO2 |
|
|
Term
|
Definition
| in periph, Hgb->H+Hgb (low pH) -> unload O2 |
|
|
Term
|
Definition
|
|
Term
| in periph, Hgb->H+Hgb (low pH)-> |
|
Definition
|
|
Term
|
Definition
|
|
Term
| what lung vols cant be measured? |
|
Definition
resid vol and therefore
FRC and TLC |
|
|
Term
|
Definition
| 80%FVC FVC= everything but RV |
|
|
Term
| restr lung dz -> FEV1 & FVC |
|
Definition
|
|
Term
| obstr lung dz -> FEV1 & FVC |
|
Definition
FEV1 dn more so
dn FEV1/FVC |
|
|
Term
|
Definition
| diff curves for insp & exp |
|
|
Term
| diff curves for insp & exp |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
blue bloaters
prod cough x>3mos/2yrs
hypertrophy of mucus glands in bronchioles (reid index >50%)
cause: us. smoking
ssx: wheezing, crackles, cyanosis |
|
|
Term
|
Definition
| wheezing, crackles, cyanosis |
|
|
Term
| wheezing, crackles, cyanosis |
|
Definition
|
|
Term
|
Definition
chronic bronchitis
emphysema
asthma
bronchiectasis |
|
|
Term
|
Definition
pink puffer
enlarg'd air spaces & dn recoil fr
destr'n of alveolar walls
causes: smoking (centriacinar)
a1 antitrypsin def (pan acinar and liver cirrh)
up elastase act'y
ssx: dyspnea, dn breath sounds, tachycardia, dn I/E ratio (insp vs exp time) |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| dyspnea, dn breath sounds, tachycardia, dn I/E ratio (insp vs exp time) |
|
Definition
|
|
Term
|
Definition
| dyspnea, dn breath sounds, tachycardia, dn I/E ratio (insp vs exp time) |
|
|
Term
|
Definition
bronchial hyperresponsiveness to reversible bronchoconstr
triggers: viral URI, allergens, stress
ssx: cough, wheeze, tachypnea, hypoxemia, dn I/E ratio, paradox pulse, curschman's spirals, sm mm hypertrophy, muc plugging |
|
|
Term
| cough, wheeze, tachypnea, hypoxemia, dn I/E ratio, paradox pulse, curschman's spirals, sm mm hypertrophy, muc plugging |
|
Definition
|
|
Term
|
Definition
| chr necr infn of bronchi-> dil'd airways, purulent sputem, rec infns, hemoptysis. Assocd w/ obstrn, CF, poor ciliary motility & kartageners |
|
|
Term
| pur sputum, rec infns, hemoptysis, +/- obstr |
|
Definition
|
|
Term
| restrictive lung dz types |
|
Definition
poor breathing mechs (extra pulm)
interstitial lung dz |
|
|
Term
| restrictive lung dz gen chars |
|
Definition
dn exp'n -> dn vols (dn VC & TLC)
PFT: FEV1/FVC>80% |
|
|
Term
| extrapulm restrictive dz types |
|
Definition
poor musc effort: polio, MG
poor structural apparatus: scoliosis, morbid obesity |
|
|
Term
| interstitial lung dz types |
|
Definition
ARDS
NRDS (hyaline membrane dz)
pneumoconioses
sarcoidosis
idiopathic pulmonary fibr
goodpastures
wegeners
eo granuloma |
|
|
Term
|
Definition
|
|
Term
| trach devn away fr lesion |
|
Definition
|
|
Term
|
Definition
dynein arm dysfn
infertility
bronchiectasis
rec sinusitis
situs inversus |
|
|
Term
infertility
bronchiectasis
recurrent sinusitis |
|
Definition
|
|
Term
|
Definition
diffuse pulm interstital fibr
up risk mesothelioma & bronchogenic CA (esp w/ tob)
long latency
ferruginous bodies in lung = asbestos coated in hemosiderin
ivory pleural plaques |
|
|
Term
| neonatal resp distress syndrome |
|
Definition
surfactant deficiency->up sfc tn -> alv collapse
should be abundant after wk 35
lec/sphing ratio <1.5
tx: mom CS b/f birth, artificial surfactant for kid |
|
|
Term
|
Definition
|
|
Term
|
Definition
| adCA, bronchoalviolar CA, lg cell |
|
|
Term
|
Definition
|
|
Term
|
Definition
central
smoking
ADH, ACTH, lambert-eaton |
|
|
Term
central lung CA
smoking
PTH |
|
Definition
|
|
Term
central lung CA
smoking
ADH, ACTH, lambert-eaton |
|
Definition
|
|
Term
|
Definition
|
|
Term
| leading cause of CA death |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| flushing, diarrhea, wheezing, salivation |
|
|
Term
|
Definition
| v common. To brain (epilepsy), bone (fx), liver (jaundice, HM) |
|
|
Term
|
Definition
| cough, hemoptysis, bronchial obstrn, wheezing, coin lesions |
|
|
Term
| cough, hemoptysis, bronchial obstrn, wheezing, coin lesions |
|
Definition
|
|
Term
|
Definition
SPHERE
SVC syndrome, Pancoasts tumor, Horners syndrome, Endocrine (paraneoplastic), Recur laryng -> hoarsness, Effusions (pleural & pericardial) |
|
|
Term
|
Definition
CA in lung apex
may affect cerv SNS plexus -> horners syndrome |
|
|
Term
CA in lung apex
may affect cerv SNS plexus -> horners syndrome |
|
Definition
|
|
Term
|
Definition
us. Pneumococcus
intraalv exudate->consolidation
may involve entire lung |
|
|
Term
|
Definition
staph aur. H. flu. Klebsiella, strep pyogens
acute infl infils bronchioles -> adj alv; patchy distr in 1+ lobe |
|
|
Term
| interstitial atyp pneumonia |
|
Definition
RSV, adenovirus, mycoplasma, legionella, chlamydia
diffuse patchy inflm loc'd to interstitial areas at alv walls
1+ lobe |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
bronchocontstr
vasoconstr
sm musc contr
up vasc perm |
|
|
Term
|
Definition
|
|
Term
| up bronchial tone (factors) |
|
Definition
|
|
Term
bronchocontstr
vasoconstr
sm musc contr
up vasc permup bronchial tone |
|
Definition
|
|
Term
|
Definition
inh platelet aggr
vasodiln |
|
|
Term
inh platelet aggr
vasodiln |
|
Definition
|
|
Term
|
Definition
dn PLA2
dn COX synth
beclomethasone, prednisone
via dn TNFa |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
dn platelet aggr
dn vasc tone
dn bronch tone
dn uterine tone |
|
|
Term
dn platelet aggr
dn vasc tone
dn bronch tone
dn uterine tone |
|
Definition
|
|
Term
|
Definition
up uterine tone
dn vasc & bronch tone |
|
|
Term
up uterine tone
dn vasc & bronch tone |
|
Definition
|
|
Term
|
Definition
up platelet aggr
up vasc&bronch tone |
|
|
Term
up platelet aggr
up vasc&bronch tone |
|
Definition
|
|
Term
|
Definition
diphenhydramine
dimenhydrinate
chorpheniramine |
|
|
Term
|
Definition
allergy
motion sickness
sleep aid |
|
|
Term
|
Definition
loratadine
fexofenadine
desloratadine |
|
|
Term
allergy
motion sickness
sleep aid |
|
Definition
|
|
Term
diphenhydramine
dimenhydrinate
chorpheniramine |
|
Definition
|
|
Term
|
Definition
sedn
antimusc
anti-a-adrenergic |
|
|
Term
sedn
antimusc
anti-a-adrenergic |
|
Definition
|
|
Term
|
Definition
|
|
Term
loratadine
fexofenadine
desloratadine |
|
Definition
|
|
Term
|
Definition
B2ag-> relax broncSM
but tachy (B1) |
|
|
Term
|
Definition
B2 ag
use during acute asthma attack |
|
|
Term
|
Definition
long acting B2 ag for asthma prophylaxis
SE: tremor, arrhythm |
|
|
Term
B2 ag
use during acute asthma attack |
|
Definition
|
|
Term
long acting B2 ag for asthma prophylaxis
SE: tremor, arrhythm |
|
Definition
|
|
Term
|
Definition
inh phosphodiesterase -> dn cAMP hydrolysis
narrow ther window (card & neurotox) |
|
|
Term
| inh phosphodiesterase -> dn cAMP hydrolysis |
|
Definition
theophylline
(methylxanthine)
narrow ther window (card & neurotox) |
|
|
Term
|
Definition
| blocks muscR-> prevents bronchoconstr |
|
|
Term
| blocks muscR-> prevents bronchoconstr |
|
Definition
|
|
Term
|
Definition
prevents mast cell release of mediators
prophylactic |
|
|
Term
prevents mast cell release of mediators
prophylactic |
|
Definition
|
|
