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trueger
neuro path 2
30
Other
Not Applicable
05/31/2006
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Term
alzheimers dz
 Definition
cerebral cortex degen
senile plaques = beta amyloid core, EC
neurofibr tangles (IC, abn phos tau)
Term
alzheimers gen
 Definition
10% familial
chr 1,14,19 = APOE4

chr 21 = p-App gene
Term
senile plaques
 Definition
alzheimers
EC
beta amyloid
Term
neurofibr tangles
 Definition
alz
IC
abnl phos tau proteins
Term
top 2 elderly dementias
 Definition
alz
multi-infarct
Term
alz compln
 Definition
amyloid angiopathy
intracranial hem
Term
cerebral cortex degen
senile plaques = beta amyloid core, EC
neurofibr tangles (IC, abn phos tau)
 Definition
alzheimers dz
Term
10% familial
chr 1,14,19 = APOE4

chr 21 = p-App gene

 Definition
alzheimers gen
Term
alzheimers
EC
beta amyloid
 Definition
senile plaques
Term
alz
IC
abnl phos tau proteins
 Definition
neurofibr tangles
Term
picks dz
 Definition
cerebral cortex degen
parkinsonian aspects
picks bodies
specific to frontal & temp lobes
Term
pick bodies
 Definition
IC aggr tau proteins
Term
cerebral cortex degen
parkinsonian aspects
picks bodies
specific to frontal & temp lobes
 Definition
picks dz
Term
IC aggr tau proteins
 Definition
pick bodies
Term
huntington dz
 Definition
BG & brain stem degen
AD - chr 4 Cag repeats
chorea, dementia
atrophy of caudate nucl (GABAergic)
Term
Parkinsons dz
 Definition
lewy bodies, depigm'd subst nigra pars compacta
loss of dopaminergic
rare: exposure tp PTPT
Term
Parkinsons dz ssx
 Definition
resting tremor, cogwheel rigidity, akinesia & postural instability
Term
olivopontocerebellar atrophy
 Definition
a spincocerebellar atrophy
Term
friedrich's ataxia
 Definition
AR
frataxin
chr 9
Term
ALS
 Definition
UMN & LMN signs
no sensory def
Term
werdnig-hoffman dz
 Definition
AR
floppy baby
tong fasiculations
med death @7mos
degen of ant horns
Term
polio
 Definition
LMN signs, anterior horn degen
Term
BG & brain stem degen
AD - chr 4 Cag repeats
chorea, dementia
atrophy of caudate nucl (GABAergic)
 Definition
huntington dz
Term
lewy bodies, depigm'd subst nigra pars compacta
loss of dopaminergic
rare: exposure tp PTPT
 Definition
Parkinsons dz
Term
resting tremor, cogwheel rigidity, akinesia & postural instability
 Definition
Parkinsons dz ssx
Term
a spincocerebellar atrophy
 Definition
olivopontocerebellar atrophy
Term
AR
frataxin
chr 9
 Definition
friedrich's ataxia
Term
UMN & LMN signs
no sensory def
 Definition
ALS
Term
AR
floppy baby
tong fasiculations
med death @7mos
degen of ant horns
 Definition
werdnig-hoffman dz
Term
LMN signs, anterior horn degen
 Definition
polio
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