Term
| How do TCAs and MAOIs relieve depression (hypothesis)? |
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Definition
1) TCAs: inhibit 5-HT and NA uptake
2) MAOIs: inhibit metabolism of 5-HT and NA. |
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Term
| What is the evidence against the monoamine hypothesis? |
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Definition
1) TCAs and MAOIs take time to work
2) No evidence of lowered 5-HT/NA or their metabolites in depressed patients. |
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Term
| What is the effect of cortisol on neurones? |
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Definition
1) Damage (less connections)
2) Lowers neurogenesis |
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Term
| How does 5-HT mediate adaptation to chronic stress? |
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Definition
1) 5-HT neurones are in the raphe nuclei
2) These neurones send axons to the cortex
3) 5-HT released onto 5-HT1a receptors
4) Damage results in learned helplessness. |
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Term
| What does lowering 5-HT in healthy patients? |
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Definition
1) Relative increases in attention to negative items
2) Relatively better recall for negative memories |
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Term
| What do SSRIs and TCAs bind to? |
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Definition
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Term
| What kind of effect does early life stress have on cortisol? |
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Definition
| Changes in HPA axis lead to the release of more cortisol. |
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Term
| What impact does cortisol have on 5-HT? |
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Definition
| Cortisol impairs 5-HT1A receptor function. |
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Term
| Which version of the 5-HTT gene increases risk of depression? |
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Definition
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Term
| Describe the receptors important in 5-HT neurones. |
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Definition
1) Somatodentritic autoreceptors: 5-HT1A
2) Terminal autoreceptors: 50HT1D
3) Postsynaptic 5-HT receptors: 5-HT1A or 5-HT2A
4) Terminal heteroceptors: alpha 2
Postsynaptic NA recptors: alpha 1 |
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Term
| Which 5-HT receptors are affected in depression? |
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Definition
1) Increased somatodendritic 5-HT1A
2) Decreased postsynaptic 5-HT1A. |
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