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Tumors Patho
Monthly 5
33
Medical
Professional
11/16/2008

Additional Medical Flashcards

 


 

Cards

Term
ODONTOGENIC TUMORS
Definition

• Epithelial origin

• Mixed origin

• Mesenchymal origin

Term

ODONTOGENIC TUMORS

• Epithelial origin

Definition
– AMELOBLASTOMA
– MALIGNANT AMELOBLASTOMA AND AMELOBLASTIC CA
– CEOT
Term

ODONTOGENIC TUMORS

• Mixed origin

Definition
– AMELOBLASTIC FIBROMA
– AMELOBLASTIC FIBRO‐ODONTOMA
– AOT
– ODONTOMA
Term

ODONTOGENIC TUMORS

• Mesenchymal origin

Definition
– CENTRAL ODONTOGENIC FIBROMA
– PERIPHERAL ODONTOGENIC FIBROMA
– ODONTOGENIC MYXOMA
Term
AMELOBLASTOMA
Definition
• Most common clinically significant
odontogenic tumor
• Frequency = combined frequency of all
other odont tumors, except odontoma
Term
AMELOBLASTOMA
Definition
• Odontogenic epithelial origin
– Cell rest of enamel organ
– Developing enamel organ
– Ep lining of an odont cyst
– Basal cells of oral mucosa
Term
AMELOBLASTOMA
Definition
• Slow‐growing, locally invasive
• 3 types
– Conventional solid or multicystic (86%)
– Unicystic (13%)
– Peripheral (extraosseous) (1%)
Term
Conventional Ameloblastoma
Definition
• Solid or Multicystic
• Swelling or expansion of jaw
• Most occur in the mandible, in the molarascending
ramus area
• Multilocular lesion ‐ "Soap bubble"
appearance
• Resorption of roots
Term
Conventional Ameloblastoma
Definition
• Ranges from simple enucleation and
curettage to en bloc resection
• Often extends beyond its apparent
radiologic or clinical margin
• Marginal resection most widely used
Term
Conventional Ameloblastoma
Definition
• High recurrence rates (50‐90%) depending
on type of surgery
• Recurrence often takes many years
Term
Unicystic Ameloblastoma
Definition
• Younger pts usually during 2nd decade
• Frequency 13%
>90% in posterior mandible, Circumscribed
lucency around the crown of an unerupted
lower 3rd
• Usually treated as cysts by enucleation
• Recurrence 10‐20%
Term
Peripheral Ameloblastoma
Definition
• Uncommon extraosseous variant, 1%
• Most lesions clinically resemble some form of
fibroma
• Innocuous clinical behavior
• Recurrent rate of 15‐20%
Term
MALIGNANT AMELOBLASTOMA
Definition
-histologic features of ameloblastoma, both in primary nd metastatic deposits
– Metastases most often in lungs ‐“Aspiration” or
“implant” metastases
– Cervical lymph nodes 2nd most common
location for metastasis
 
• Xray & Histology
– similar to normal ameloblastoma
• Prognosis is poor.
Term
AMELOBLASTIC CARCINOMA
Definition
-ameloblastoma that has malignant features
– Follow markedly aggressive course
– Metastases do not necessarily occur
 
• Xray
-more aggressive
• Histology
– show malignant cytologic features
 
-Prognosis is poor.
Term
CALCIFYING EPITHELIAL ODONTOGENIC TUMOR
Definition
• Also called, Pindborg Tumor
• Close resemblance to stratum intermedium of the
enamel organ
• Betwn 30‐50 yrs of age
• 75% in mand, mostly posterior
• Unilocular or multilocular lucency
• May contain calcified structures
Term
CALCIFYING EPITHELIAL ODONTOGENIC TUMOR
Definition
• Frequently assoc with impacted tooth
• Nuclei show pleomorphism
• May be mistaken for metastatic disease
• Recurrence rate 15%
Term
SQUAMOUS ODONTOGENIC TUMOR
Definition
Clinical features
• Rare,benign od tumor ‐1975 (40 cases)
• Mean age 38y, multifocal reported
• Equal jaw distribution
• Equal sex predilection
• Painless/mild pain ‐ gingival swelling
• Tooth mobility
• Triangular RL (Perio bone loss)
Term
SQUAMOUS ODONTOGENIC TUMOR
Definition
Tx & prognosis
• Wide surgical excision
• Curative
• No recurrence
• Maxillary lesions more aggressive
• 1 report of malignant transformation
• Solitary lesions more aggressive
Term
AMELOBLASTIC FIBROMA
Definition
• True mixed tumor
• Young patients in the first two decades
• Most in post mand in perm 1st/2nd molar area
• Either unilocular or multilocular
• 50% assoc with unerupted tooth
• Recurrence after conservative excision
Term
AMELOBLASTIC FIBROODONTOMA
Definition
• Like AF (AMELOBLASTIC FIBROMA) but with enamel and dentin
• May represent a stage of odontoma
• May cause deformity & bone destruction
• Usually in children around 10 years
• Equal in both jaws
• May prevent tooth eruption
Term
AMELOBLASTIC FIBROODONTOMA
Definition
-Well‐circumscribed unilocular (rarely
multilocular) may have calcifications
• May be associated with unerupted tooth
• Treatment – curettage with excellent
prognosis
Term
AMELOBLASTIC FIBROSARCOMA
Definition
• Ameloblastic sarcoma
• Malignant – Ameloblastic fibroma
• 50 cases
• M: F, 1.5:1
• Younger, mean 27.5 yrs
Term
AMELOBLASTIC FIBROSARCOMA
Definition
• 80% , Mandible
• Pain, swelling , rapid clinical growth
• Ill ‐ defined radiolucency
• Radical surgical escision
• Death is due touncontrolled local disease
• 1 metastasis in 49 evaluated cases
Term
ADENOMATOID ODONTOGENIC TUMOR
Definition
• Limited to younger patients 10‐19 yrs
• Striking tendency for anterior maxilla
• F:M = 2:1
• Circumscribed, radiolucency around crown of
an unerupted canine
• Easily enucleates from bone due to capsule
Term
ODONTOMA
Definition
• Most common odontogenic tumor
• Prevalence exceeds all other tumors combined
• Considered to be developmental anomalies
(hamartomas) rather than true neoplasms
• Divided into compound and complex types
Term
ODONTOMA
Definition
• Seen during the first two decades, mean age 14
• Relatively small and seldom exceed the size of
a tooth
• Frequently assoc with an unerupted tooth and
prevents eruption of the tooth
• Treated by simple local excision
Term
Compound Odontoma
Definition
• Composed of multiple, small tooth‐like
structures
• More common in the anterior maxilla
• Presents as a collection of tooth‐like
structures of varying size
Term
Complex Odontoma
Definition
• Mass of enamel and dentin, with no
resemblance to teeth
• More often in the molar regions of either jaw
• Presents as a calcified mass with the
radiodensity of tooth structure
Term
CENTRAL ODONTOGENIC FIBROMA
Definition
• Occurs in adults
• Marked female predilection
• Both maxilla and mandible in posterior region
• Larger lesions may cause expansion or
loosening of teeth
Term
CENTRAL ODONTOGENIC FIBROMA
Definition
• X‐ray: Well‐defined, unilocular, lucency
– Larger lesions may be multilocular
• Treatment : enucleation and curettage
• Limited growth potential
Term
PERIPHERAL ODONTOGENIC FIBROMA
Definition
• Soft‐tissue counterpart
• Firm, slow‐growing sessile gingival mass
• Indistinguishable from other “bump on the
gum” entities
• Seen on facial mandibular gingiva, usually 1.5
to 3.5 cm & may displace teeth
• Surgical excision with excellent prognosis
Term
ODONTOGENIC MYXOMA
Definition
• Arise from odontogenic mesenchyme
• Young adults, average 25‐30 yrs
• Found in almost any area
• Unilocular or multilocular
• Large _______ of mand show a "soap
bubble" appearance indistinguishable from
ameloblastomas
Term
ODONTOGENIC MYXOMA
Definition
• Small lesions by curettage
• Larger lesions by more extensive resection
• Not encapsulated and tend to infiltrate the
surrounding bone
• May recur
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