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The removal of organic waste products from body fluids |
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The discharge of waste products into the environment |
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Homeostatic regulation of blood plasma |
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Regulating blood volume and pressure Regulating plasma ion concentrations Stabilizing blood pH Conserving nutrients Detoxification of poisons |
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Produce urine via nephrons |
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Transport urine from kidneys to bladder |
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Temporary Stores urine (700-800 cc) |
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Transports urine out of body |
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Reproductive and urinary structure in males |
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Transports semen and urine) |
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Remove metabolic wastes from blood by filtration Wastes eliminated as aqueous solution called urine Regulate blood volume and blood pressure Secrete hormone renin Stimulate RBC production from RBM Secrete erythropoietin (EPO) Metabolize vitamin D Convert it to active form (calcitriol) |
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Between T12 and L3 Somewhat protected by lower part of rib cage |
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indentation on medial surface |
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Both kidneys and adrenal glands |
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Entry for renal artery and renal nerves Exit for renal veins and ureter |
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Renal Capsule/ Adipose Capsule |
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Kidneys held in place and protected by |
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collagen fibers on kidney’s outer surface |
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thick layer of adipose tissue external to capsule Cushions and attaches kidneys |
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dense fibrous connective tissue Connected to renal capsule and surrounding structures |
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Damage to fascia or adipose tissue can cause |
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Kidneys drop to lower position May prevent urine from exiting through ureter |
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Reddish brown outer portion of kidney Contains nephrons Extends into medulla as renal columns |
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consists of 6-18 renal pyramids Base of each pyramid is next to cortex |
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Major and minor calyces along with the pelvis |
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Drain urine to the ureters |
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Recieve 20-25 percent of total cardiac ouput |
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recieves blood through renal artery |
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filter 1200 ml of blood flow |
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Each kidney receives blood from a renal artery which branches into |
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Segmental arteries Interlobar arteries Arcuate arteries Interlobular arteries afferent arterioles |
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recieve blood from renal artery |
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Divide into interlobar arteries: which radiate outward through renal columns between renal pyramids |
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Supply blood to arcuate arteries: which arch along boundary between cortex and medulla of kidney |
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branch from each interlobular artery and deliver blood to capillaries supplying individual neprhons. |
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Deliver blood to arcuate veins Empty into interlobar veins: which drain directly into renal vein |
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Innervate kidneys and ureters Enter each kidney at hilum Follow tributaries of renal arteries to individual nephrons |
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Adjusts rate of urine formation: by changing blood flow and blood pressure at nephron |
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Stimulates release of renin: which restricts losses of water and salt in urine by stimulating reabsorption at nephron |
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Functional unit of kidney |
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most of nephron located in |
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found partially or completely in medulla |
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each neprhone recieves direct blood supply |
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portion of nephrons surrounded by capillary bed |
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Composed of glomerular ( Bowman’s) capsule and the glomerulus |
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Proximal convoluted tubule (PCT) Loop of Henle Distal convoluted tubule (DCT) |
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surrounded by peritubular capillaries is continuous with collecting system Collecting duct Papillary duct |
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Production of filtrate Processed along renal tubule to become urine Reabsorption of organic nutrients Reabsorption of water and ions Secretion of waste products into filtrate Secretion of hydrogen and bicarbonate ions into filtrate Adjusts pH of blood |
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~85% of all nephrons Located almost completely in the cortex Bottom of loop of Henle in medulla |
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Specialized to regulate water content of urine Allows water conservation Have specialized capillaries called vasa recta |
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Blood Flow through Nephron |
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Blood enters glomerulus through afferent arteriole Blood exits glomerulus through efferent arteriole Blood travels from efferent arteriole to peritubular capillaries and vasa recta Capillaries allow reabsorption of substances that are not excreted |
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loop of offnestrated capillaries |
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inner visceral layer and outer parietal layer |
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filters blood and produces glomerular filtrate |
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cells of visceral layer of glomerular capsule |
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parietal layer of glomerular capsule |
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formed by simple squamous cells |
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Difference between glomerulus and capillaries |
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. Tangled cluster/ball of blood capillaries 2. Surrounded by glom capsule 3. kidneys have “podocytes in their capillaries whereas regular body capillaries have “fenestrated slits”. 4. Also kidneys filter other fluid that is in the renal corpuscle. |
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Proximal Convoluted Tubule |
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Actively reabsorbs nutrients, plasma proteins and ions from filtrate Responsible for most of reabsorption Nutrients released into peritubular fluid and absorbed by peritubular capillaries |
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Descending limb Ascending limb Each limb has a thick and thin section |
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Actively secretes ions, toxins, drugs Reabsorbs sodium ions from tubular fluid |
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Extreting Waste Products: -urea -Creatinine -Uric Acid |
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requires coupling micturition reflex with relaxation of external urethral sphincter |
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Urination coordinated by micturition reflex |
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Initiated by stretch receptors in wall of bladder Initiated when bladder fills with 200 ml urine |
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Extends from the urinary bladder to the exterior of the body |
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Passes through urogenital diaphragm Forms external urinary sphincter Skeletal (voluntary) muscle |
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Contains Rugae for expansion |
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reservoir for the storage of urine |
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can hold up to 500 ml urine |
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contraction of this voids bladder |
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3 layers of smooth muscle |
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how many and what kind of muscle are in the bladder wall |
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triangular region near urethra Directs urine toward urethra |
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contains internal urethral sphincter Smooth muscle that controls discharge of urine |
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Pair of muscular tubes Layer of smooth muscle in wall Extend from renal pelvis to the bladder Peristaltic contractions force urine toward the urinary bladder |
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Filtration in the renal corpuscle Nutrient reabsorption along the PCT Active secretion at PCT and DCT Loops of Henle regulate final volume and solute concentration |
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Blood passes through the Afferent Arteriole Efferent Arteriole Glomerulus - PCT descending L of H Ascending L of H DCT into the collecting duct into the Minor Calyx Major Calyx Final step is it moves into the URETER into the Urinary bladder for temporary storage Tinkle |
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regulated by aldosterone and ADH |
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Sodium ions, bicarbonate ions, and urea are reabsorbed |
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pH is controlled by secretion of hydrogen or bicarbonate ions |
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Varies with the metabolic and hormonal events of the body Reflects filtration, absorption and secretion activity of the nephrons Urinalysis is the chemical and physical analysis of urine |
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