Term
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Definition
5-α-reductase inhibitor
blocks testosterone from becoming dihydrotestosterone
Tx. BPH, male pattern baldness |
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Term
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Definition
oral anti-fungal
squalene epoxidase inhibitor
Tx. tinea capitis (topical antifungal doesn't penitrate |
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Term
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Definition
inhibits microtubular polymerization
prevents aggregation of MT subunits
disrupts membrane-dependent functions like chemotaxis and phagocytosis of PMNs.
Also used for karyotyping
Used to treat gout |
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Term
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Definition
block bacterial dihydrofolate reductase
blocks folic acid synthesis - needed for pyrimidine synthesis
is an antibiotic
may interact w/ human enzymes |
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Term
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Definition
Blocks human dihydrofolate reductase
inhibits tetrahydrofolate production from dihydrofolate
THF needed in pyrimidine synthesis
is a cancer chemotherapy drug |
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Term
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Definition
blocks parasitic dihydrofolate reductase, inhibiting tetrahydrofolate from dihydrofolate - prevents pyrimidine synthesis.
Treats malaria |
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Term
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Definition
| binds to DNA causing an unraveling of the helix, breaks the strands, thereby inhibiting protein synthesis and the cell dies. |
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Term
Imipenem
-also what drug is commonly given with this and why? |
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Definition
blocks Peptidoglycan synthesis last step in bacteria by binding to the penicillin binding proteins
Cilastatin prevents renal metabolism of this drug by inhibiting dehydropeptidase on renal tube brush border |
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Term
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Definition
| Blocks mucopeptide transfer into cell wall, blocking bacterial wall synthesis. |
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Term
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Definition
| Treats giardia, H. pylori, amebiasis, and trichomoniasis |
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Term
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Definition
| treats helmenths such as Ascaris, Ancylostoma, and Enterobius by acting on microtubules |
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Term
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Definition
| treats cestode tapeworm Echinococcus granulosis |
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Term
| Mesna, or "2-mercaptoethanesulfonate" |
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Definition
| What can you give with cyclophosphamide or ifosfamide to prevent hemorrhagic cystitis? |
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Term
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Definition
inhibits serotonin (5-HT) receptors
Tx nausea and vomiting |
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Term
| Pyridoxine (B6) in the setting of renal stones - why? |
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Definition
| it decreases endogenous oxalate production decreasing the rate of calcium stone formation in urinary tract |
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Term
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Definition
| Diuretic via blocking carbonic anhydrase, preventing HCO3 resorption - acidifies urine and alkalinizes the blood. |
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Term
| Epleronone or spironolactone |
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Definition
aldosterone inhibitors which reduce sodium and water reabsorption in kidneys.
**ONLY DIURETIC TYPE TO INCREASE SURVIVAL IN CONGESTIVE HEART FAIL |
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Term
| SHIPP - Sulfalazine, Hydralazine, Isoniazide, Phenytoin, and Procainamide - unique side effect and metabolism of these drugs |
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Definition
Can cause drug induced lupus (anti-histone antibodies)
the two most high risk (second and last listed) Metabolized by acetylation in Liver |
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Term
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Definition
| anti fungal via microtubule action |
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Term
| Vincristine / Vinblastine |
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Definition
| Cancer chemo - acts on microtubules |
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Term
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Definition
Cancer chemo, breast cancer
acts on microtubules |
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Term
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Definition
| non-competitive irreversable alpha 1 and alpha 2 antagonist |
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Term
| Tricyclic overdose typically develops what type of symptoms? |
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Definition
| Anticholinergic symptoms, cardiac conduction issues. |
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Term
| Para-aminobenzoic acid (PABA) sunscreen blocks which type(s) of UV rays? |
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Definition
blocks UVB only - the major cause of sun skin damage
does not block UVA I or II light |
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Term
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Definition
non-specific alpha adrenergic block. Vasodilates via alpha 1 block (may cause reflex tachycardia due to drop in BP)
but the alpha 2 inhibition may increase sympathetic tone (also causes tachycardia) |
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Term
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Definition
| acetylcholinesterase inhibitor - competitive |
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