Term
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Definition
| Myristoyl anchor, palmitoyl anchor, farnesyl anchor |
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Term
| Drug delivery across BloodBrainBarrier: |
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Definition
| 1.Inhibit efflux pumps 2.Couple something w/actively transported molecule 3.Open up tight junctions |
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Term
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Definition
| The 'gel' like substance. Takes up bulk of ECM. Helps receptors, sequestering ligands. |
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Term
| Fibrous/Adhesive Proteins in the ECM |
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Definition
Collagen IV is an example.
Give the ECM elasticity and tensile strength. "The rebar to the concrete(GAGs)" |
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Term
| In ER, Oligosaccharides are added to: |
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Definition
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Term
| Paroxysmal nocturnal hemoglobinuria: |
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Definition
| Mutation in PIG-A. Catalyzes 1st step in GPI anchoring. Usually protects RBCs from complement lysis. |
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Term
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Definition
Alpha-1-antitrypsin deficiency.
Elastase is not inhibited, so it eats up the elastin in lung tissue. Smoking w/this guarantees cancer. |
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Term
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Definition
| Mutation in Chloride channel due to failed export of a protein from ER. |
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Term
| O-linked Oligosaccharide addition: |
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Definition
| Happens in Golgi. Added one-by-one to Ser/Thr residues. |
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Term
| Destination of Proteins Leaving Golgi: |
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Definition
| Lysosome, CellMembrane (constitutive), Secretory vesicles (signal mediated) |
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Term
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Definition
| Targeting signal added to proteins to go to lysosome. Binds to golgi membrane M6P receptors and clathrin binds outside to form vesicle. |
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Term
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Definition
vSNARES - on vesicle
tSNARES - on target
a-helices wrap around each other acting as winches to fuse membranes. |
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Term
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Definition
| Blocks AcH release by cleaving synaptic vSNARES and tSNARES |
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Term
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Definition
| Pinocytosis (constitutive), Phagocytosis (Triggered for large molecules) |
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Term
| Familiar Hypercholesterolemia |
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Definition
High blood LDL levels.
3 Possibilities: LDL receptor not made, doesn't bind, or doesn't internalize the LDL. |
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Term
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Definition
| Organelles and cytosol are engulfed by internal membrane and delivered to the lysosome. |
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Term
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Definition
Ran-GDP higher in cytosol.
Ran-GTP higher in nucleus.
Loading favored in cytosol, release favored in nucleus. Ran-GAP dephosphorylates Ran-GTP as it comes into cytosol. |
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Term
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Definition
Make H2O2 and such.
Makes Plasmalogen. Which makes most myelin phospholipids. |
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Term
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Definition
| Peroxisomes are empty. Defects in import pathway (Pex2 Transporter) |
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Term
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Definition
Maintain cell homeostasis. Generated and used rapidly. In all cells.
Derived from ER, monolayer of phospholipids. |
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Term
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Definition
| Defect in Dystrophin. Binds Actin to cell membrane. Severe muscle weakness. |
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Term
| Microtubule Motor Proteins |
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Definition
Kinesin: towards (+) end
Dynein: towards (-) end |
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Term
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Definition
| Immobile Cilia. Missing Dyneins. Causes infertility and lung infections. Organ position reversed. |
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Term
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Definition
Hutchinson-Gilford Progeria Syndrome.
Mutation in LaminA so it isn't removed after Farnesyl anchoring to nuclear membrane. Premature aging. |
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Term
| Polycystic Kidney Disease |
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Definition
| Due to defects in the primary (sensory) cilia used in cell-to-cell communication. Kidney cells just keep multiplying. |
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Term
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Definition
| Carb coat on surface of actin microvilli in intestinal epithelium. |
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Term
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Definition
| Found in Epidydimas and Inner ear. Actin. |
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Term
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Definition
| Occluding (Tight), Communication (Gap), Anchoring (Desmosomes, Hemidesmosomes) |
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Term
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Definition
| Connect cell to other cells using Cadherins. Anchor junctions. |
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Term
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Definition
| Connects cell to ECM using Integrins. Anchor junctions. |
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Term
| In Gap Junctions, what regulates the conductance? |
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Definition
| cAMP. "Increased cAMP closes the GAP" |
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Term
| Connect Actin to Cadherins: |
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Definition
| Catenins. Examples include Vinculin and Actinin. |
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Term
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Definition
| Pumps 3 Na+ out and 2 K+ in. P-type that auto-phosphorylates itself. |
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Term
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Definition
| Have 2 ATP binding sites. Malaria protists overexpress it to pump out drugs, as do cancer cells. |
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Term
| 3 Major Types of Signal Receptors: |
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Definition
| Ion Channel, G-Protein, Enzyme Linked |
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Term
| Types of Enzyme-Linked Receptors: |
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Definition
P-Type: Autophosphorylate (Na/K pump)
F/V Types: turn mech energy into chemical (ATP synth)
ABC: 2 ATP binding sites (efflux pumps) |
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Term
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Definition
| Mutation in hydrolase delivery. Empty lysosomes. |
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Term
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Definition
Build up of gangliosides due to lack of HexA.
"Gangs sack buildings" |
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Term
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Definition
| ATP synthase. Also pump H+ to alter pH. |
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Term
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Definition
Cation pumps. Na+/K+ pumps.
"P is positive. Cations" |
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Term
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Definition
| Regulates Synaptic Vesicle Exocytosis. Binds the vSNARES preventing exocytosis. When Ca++ comes in it binds it causing it to release the vSNARE |
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