Term
| Classification of Wegener Granulomatosis |
|
Definition
1) upper and lower respiratory tract
2) kidneys
3) necrotizing GN with no immune deposit
4) ANCA positive w/c-ANCA
5) tx w/cyclophosphamide |
|
|
Term
| Classification of Polyarteritis |
|
Definition
1) Any system involvement
2) Necrotizing GN with no immune deposit
3) ANCA positive w/p-ANCA
4) tx w/ prednisone if mild, cyclophosphamide if severe |
|
|
Term
| Classification of Hypersensitivity Vasculitis |
|
Definition
1) skin purpura and renal disease
2) Proliferative GN w/immune complex deposits
3) negative ANCA
4) tx w/cyclophosamide and prednisone if severe |
|
|
Term
| what can be detected in 90% of wegner granulomatosis patients? |
|
Definition
|
|
Term
| p-ANCA is more common in which disorders? |
|
Definition
1) microscopic polarteritis
2) idiopathic necrotizing rapidly progressive GN |
|
|
Term
| tx for wegner granulomatosis? |
|
Definition
|
|
Term
| What are the 4 forms of polarteritis and Churg-Stauss syndrome? |
|
Definition
1) Classic polyarteritis nodosa-aneurysms
2) Microscopic polarteritis nodosa-smaller vessels than classic
3) Churg-Strauss syndrome-eosinophilic infiltration
4) Overlap syndrome
4) |
|
|
Term
| What diagnostic finding is common in Churg Strauss? |
|
Definition
| lung involvement w/bronchospasm |
|
|
Term
| What diagnostic finding is commmon in classic polyarteritis nodosa? |
|
Definition
|
|
Term
| what manifests as a palpable purpuric rash? |
|
Definition
| leukocytoclastic vasculitis |
|
|
Term
| What is the classic tetrad for Henocho-Schonlein purpura? |
|
Definition
1) abdominal pain
2) purpuritic skin rash
3) arthritis/arthralgias
4)GN |
|
|
Term
| What is the most common underlying cause of mixed cryoglobulinemia? |
|
Definition
|
|
Term
| What is commonly present with mixed cryoglobulinemia? |
|
Definition
|
|
Term
| What medications cause serum sickness? |
|
Definition
1) penicillins
2) sulfonamides
3) phenytoin |
|
|
Term
| What are the 3 hypersenstivity vasculitis? |
|
Definition
1) Henoch-Schonlein purpura
2) Mixed cryoglobulinemia
3) Serum Sickness |
|
|
Term
| What are the most common organs involved with scleroderma? |
|
Definition
| lungs, GI, Heart, Kidneys |
|
|
Term
| What diagnostic findings point towards scleroderma? |
|
Definition
1) Marked BP elevation
2) raynaud phenomenon
3) antinuclear antibodies |
|
|
Term
| What are Hemolytic uremic syndrome (HUS) disorders characterized by? |
|
Definition
1) microangipathic hemolytic anemia
2) thrombocytopenia,
3) varying degrees of renal failure |
|
|
Term
|
Definition
1) fever
2) thrombocyopenia
3) focal neurological abnormalities
4) microangiopathic hemolytic anemia
5) renal failure |
|
|
Term
| What is frequently found in childhood HUS? |
|
Definition
1) bloody diarrhea
2) hypertension w/renal failure |
|
|
Term
| What is frequently found in the UA for HUS? |
|
Definition
|
|
Term
| When is preeclampsia most common? |
|
Definition
| 3rd trimester of first pregnancy |
|
|
Term
| What 3 anti-HTN meds are safe during pregnancy? |
|
Definition
1) methyldopa
2) hydralazine
3) labetalol
*do not use ACE-inhibitors/diuretics |
|
|
Term
| What labs are highly suggestive of renal infartction? |
|
Definition
1) elevated LDH (>5X normal)
2) little/no transaminase elevation |
|
|
Term
| What is the principle renal manifestation of skickly cell nephropathy? |
|
Definition
|
|
