Term
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Definition
Use: Leukemias, lymphomas, choriocarcinoma, sarcoma Abortion, ectopic pregnancy, RA, psoriasis
Mech: An antimetabolite Inhibits nucleotide synthesis (thymidine) Inhibits dihydrofolate reductase A folic acid analog
Tox: Myelosuppression (*reversible with leucovorin) Fatty change to liver Mucositis Teratogenic
Contraindications: Pregnancy |
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Term
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Definition
Use: Solid tumors, colon cancer, basal cell carcinoma (topical) Synergy with MTX.
Mech: An antimetabolite Inhibits nucleotide synthesis (thymidine) Inhibits thymidylate synthase A pyrimidine analog (5F-dUMP), which complexes with folic acid
Tox: Myelosuppression (*not reversible with leucovorin) Treat and OD with thymidine Photosensitivity.
Contraindications: |
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Term
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Definition
Use: Leukemias and Lymphomas other than CLL/Hodgkins.
Mech: An antimetabolite Inhibits nucleotide synthesis (purine) A purine analog Activated by HGPRTase.
Tox: Bone marrow, GI, liver Increased toxicity with allopurinol* Metabolized by xanthine oxidase.
Contraindications: |
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Term
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Definition
Use:
Mech: An antimetabolite
Tox:
Contraindications: |
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Term
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Definition
Use:
Mech: An antimetabolite
Tox:
Contraindications: |
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Term
List some common Antimetabolite drugs |
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Definition
MTX 5-FU 6-MP 6-TG ara-C
* all hit at S phase to inhibit DNA synthesis |
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Term
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Definition
reverses myelosuppression of MTX |
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Term
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Definition
Reverses myelosuppression of 5-FU |
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