Term
| most common pathological cause of hirsutism: |
|
Definition
| anovulation and xs androgen production by ovaries |
|
|
Term
| terminal hair first appears where in hirsutism: |
|
Definition
| lower abd and around nipple area |
|
|
Term
|
Definition
| masculinization of a woman |
|
|
Term
| adipose tissue contributes up to 50% of this hormone causing virilizatoin: |
|
Definition
|
|
Term
|
Definition
1. androstenedione (adrenal/ovaries)
2. DHEA (adrenals)
3. testosterone (adrenal/ovaries/fat) |
|
|
Term
| hormone cascade from pituitary to ovarian testosterone production: |
|
Definition
| LH from pituitary stimulates theca cells in ovary to produce androstenedione and testosterone which is normally converted to estrogen by the granulosa cells, androstenedione is converted to estrone by fat and has PFB onto LH secretion |
|
|
Term
| hirsute women have ___ levels of sex hormone binding globulin |
|
Definition
| decreased; only 1% below normal women though |
|
|
Term
| what stimulates the liver to produce SHBG (sex hormone binding globulin) |
|
Definition
|
|
Term
| SHBG production is decreased by:4 |
|
Definition
1. androgens
2. insulin
3. Decreased Estrogen
4. Decreased T4 |
|
|
Term
| SHBG production increased by:2 |
|
Definition
1. estrogen
2. thyroid hormone |
|
|
Term
| 2 most common syndromes assoc w androgen xs: |
|
Definition
|
|
Term
| 4 tumors that cause androgen xs: |
|
Definition
1. sertoli-leydig cell tumors
2. gynandroblastoma
3. lipid cell tumors
4. hilus cell tumors |
|
|
Term
|
Definition
1. oligo/amenorrhea
2. acne
3. hirsutism
4. infertility |
|
|
Term
| in PCOS what is the LH:FSH ratio? |
|
Definition
| 3:1 or higher - wo FSH there is no mature follicles to be stimulated to ovlate by LH |
|
|
Term
| in PCOS which is in greater concentrations, estrone or estradiol? |
|
Definition
|
|
Term
|
Definition
| HyperAndrogeism Insulin Resistance - Acanthosis Nigricans; subgroup of PCOS |
|
|
Term
| tx for HAIR-AN syndrome that reduces androgens and insulin levels |
|
Definition
|
|
Term
| most common therapy for PCOS |
|
Definition
| admin of oral contraceptives |
|
|
Term
| affects of contraceptives on PCOS: |
|
Definition
|
|
Term
| more severe form of PCOS w temporal balding, clitoral enlargement, voice deepening |
|
Definition
|
|
Term
| US findings on hyperthecosis: |
|
Definition
| enlarged ovaries, dense stroma, no cystic activity |
|
|
Term
| ovarian neoplasm thats secretes testoserone: |
|
Definition
|
|
Term
| describe the sx of the two overlapping stages of sertoli-lydig timor: |
|
Definition
first stage: amenorrhea, breast atrophy, loss of subcutaneous fat
second stage: masculinization, clitoral hypertrophy, hirsutism and deepening voice |
|
|
Term
| FSH/LH levels in sertoli-lydig tumor |
|
Definition
|
|
Term
| 3 adrenal androgen excess disorders |
|
Definition
1. congenital adrenal hyperplasia
2. cuushing's
3. adrenal neoplasms |
|
|
Term
| key hormone is congenital adrenal hyperplasia: |
|
Definition
|
|
Term
| 2 enzyme def that can lead to hirsutism/virilization |
|
Definition
1. 21-hydroxylase
2. 11B-hydroxylase |
|
|
