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WSU Pathophysiology Unit 6 Chapter 10
Stress and Disease
12
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Undergraduate 2
07/11/2011

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Term
Stressors:
Definition
Physical or psychologic.
Eustress vs distress.
Term
Distress is:
Definition
A condition in which a demand exceeds a person's coping ability.
Term
Stress is:
Definition
Not an independent entity but a system of processes controlled by nature, intensity, and duration of the stressor.
Term
Stress Response (General Adaptation Syndrome):
Definition
Alarm stage.
Resistance Stage.
Exhaustion Stage.
Term
The Alarm stage:
Definition
Activation of the Central Nervous System. Sympathetic response. Norepinephrine release increases cardiac output, blood pressure, promotes hyperglycemia. Causes vasoconstriction in the skin, viscera, extremities, and kidneys. Causes vasodilation of vessels in heart, skeletal muscles, and smooth muscle of the bronchi.
Term
The Resistance Stage:
Definition
Activation of the sympathetic nervous system causes the hypothalamus to stimulate the pituitary gland resulting in: Adrenal cortex secretes ACTH (controls cortisol and aldosterone), adrenal medulla secretes epinephrine and norepinephrine, pituitary secretes TSH, Increases HGH, increases release of ADH from posterior pituitary.
Term
Cortisol:
Definition
Increases protein catabolism, hyperglycemia, and delays healing process. Promotes lipolysis in adipose tissue, increases gastric secretion, and anti-inflammatory effects. Overall decrease in the immune response.
Term
TSH:
Definition
Increased thyroxin (increased BMR).
Term
Aldosterone:
Definition
Increases sodium and water retention. Increases blood volume and pressure.
Term
Aldosterone:
Definition
Increases sodium and water retention. Increases blood volume and pressure.
Term
ADH:
Definition
Water retention, increased blood volume and pressure.
Term
The Exhaustion stage:
Definition
Continuous uncompensated stress disease can result. Cardiovascular (coronary artery disease, hypertension, stroke and arrhythmias), Muscles (Tension headache and muscle contractions), and Connective tissues (Rheumatoid arthritis and inflammatory diseases of connective tissues Myofascial pain syndrome).
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